Ajinomoto Co., Ltd.

Maiko Mori

Kenzo Yokozeki

Shunichi Suzuki

Masakazu Sugiyama

Yasuhiro Mihara

Yoshiyuki Takahara

Takami Maekawa

Each gene in a group comprising many genes is cloned into an expression vector so that its gene product should be expressed as a fusion protein with a protein emitting self-fluorescence to construct a gene expression library. The gene expression library is introduced into cells of two groups to express the fusion proteins in the cells, and only one cell group is stimulated by a drug or the like. Then, cells in which the fusion proteins are localized in the nuclei or their nuclei are isolated from cells of the two groups, respectively. By comparing these cells, genes coding for proteins that are transported into the nuclei specifically in response to a certain stimulus when the stimulus is applied to the cells are retrieved.

Method of searching for gene encoding nuclear transport protein

A method for producing xylitol by allowing a microorganism belonging to the or and having a D-arabitol dehydrogenase activity and a D-xylulose reductase (xylitol dehydrogenase) activity and an ability to convert D-arabitol to xylitol is acted on D-arabitol in a reaction mixture containing a carbon source to produce xylitol.

Process for preparing xylitol

Growing community of inventors

Kawasaki, Japan

Maiko Mori