Genentech, Inc.

Five Prime Therapeutics, Inc.

F. Hoffmann-La Roche Ag

Maike Schmidt

Jo-Anne Hongo

Weilan Ye

Nels P Nielson

David Bellovin

Kathy Miller

Luis Borges

Majid Ghoddusi

Charles Kaplan

Derrick Houser

Gloria Brattich

Felicia Kemp

Yan Wu

Ellen Filvaroff

Ryan Jefferson Watts

Hartmut Koeppen

Mallika Singh

Carlos Bais

Christopher Adam Callahan

Leon H Parker, Iv

Matthew Brauer

Jo-Anne S Hongo

Leon H Parker

The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human B7-H4 (and optionally cynomolgus monkey, mouse, and/or rat B7-H4) and compositions comprising such antibodies or antigen-binding fragments thereof. In a specific aspect, the antibodies or antigen-binding fragments thereof that specifically bind to human B7-H4 increase T cell proliferation, increase interferon-gamma production, and/or deplete B7-H4 expressing cells via ADCC activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering an antibody or antigen-binding fragment thereof that specifically binds to human B7-H4.

B7-H4 antibodies and methods of use thereof

The invention provides methods and compositions to detect expression of one or more biomarkers for identifying and treating patients who are likely to be responsive to VEGF antagonist therapy. The invention also provides kits and articles of manufacture for use in the methods.

Biological markers for identifying patients for treatment with VEGF antagonists

The invention provides anti-NRP1 antibodies and methods of using the same.

Anti-neuropilin antibodies and methods of use

The present invention provides methods of using EGFL7 antagonist to modulate vascular development. Also provided herein are methods of screening for modulators of EGFL7 activity. Furthermore, methods of treatment using EGFL7 antagonists are provided.

Compositions and methods for modulating vascular development

The invention provides anti-EGFL7 antibodies, and compositions comprising and methods of using these antibodies.

Antibodies to EGFL7 and methods for their use

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San Francisco, CA, United States of America

Maike Schmidt