University of California

Maie St John

Zachary D Taylor

Warren S Grundfest

Oscar Magnus Stafsudd

Daniel Takashi Kamei

Daniel William Bradbury

Ashley Elizabeth Kita

George Saddik

Ashkan Maccabi

Pei-Chi Jiang

Peter A Pellionisz

Asael Papour

Zachary Deis Taylor

A system for selective spectral illumination in an operating room includes a housing, at least one light source disposed within the housing, the at least one light source configured to emit electromagnetic radiation at a plurality of wavelengths, and a controller coupled to the at least one light source and configured to control the at least one light source to emit electromagnetic radiation at one or more of the plurality of wavelengths based on a status of operation of an optical imaging system in the operating room.

Method and system for selective spectral illumination for optical image guided surgery

Devices and methods are provided for the detection of CSF in a biological sample. In certain embodiments the device is a lateral flow device comprising: a porous substrate; a sample addition zone disposed on or in said porous substrate; a detection zone disposed on or in said porous substrate where said detection zone comprises at least a first test line (T) and a second test line (T) each test line comprising binding moieties that bind a complex formed between beta-trace protein (βTP) and an indicator attached to a βTP binding molecule; wherein said porous substrate defines a flow path through which a sample applied to the sample addition zone flows under capillary action away from said sample addition zone into said detection zone; and wherein said first test line (T) and said second test line (T) are is configured so that either no test line signal or just a signal at the first test line (T) is detectable when βTP concentration in a sample applied to said device is lower than the βTP level indicative of a CSF leak; and said second test line (T) is configured so that a signal is detectable at said second test line when βTP concentration in a sample applied to said device is greater than the βTP level indicative of a CSF leak.

Semi-quantitative lateral-flow immunoassay for the detection of CSF leaks

A vibro-acoustography imaging system that generates a map of the mechanical response of a target to an acoustic radiation force, usually in low kHz range by a confocal geometry. The system generates two focused sinusoidal beams to produce a stress field at the beat frequency, which is a function of vibration and acoustic emissions field in terms of mechanical properties. A highly sensitive hydrophone is then used for detection of the acoustic emissions field, the amplitude of which may be correlated to the mechanical properties of the target tissue.

Multi-frequency harmonic acoustography for target identification and border detection

Devices and methods are provided for the detection of CSF in a biological sample. In certain embodiments the device is a lateral flow device comprising: a porous substrate; a sample addition zone disposed on or in said porous substrate; a detection zone disposed on or in said porous substrate where said detection zone comprises at least a first test line (T) and a second test line (T) each test line comprising binding moieties that bind a complex formed between beta-trace protein (betaTP) and an indicator attached to a betaTP binding molecule; wherein said porous substrate defines a flow path through which a sample applied to the sample addition zone flows under capillary action away from said sample addition zone into said detection zone.

A time-resolved fluorescence imaging (TRFI) system that images a target medium without lifetime fitting. Instead of extracting the lifetime precisely, the system images the fluorophore distribution to allow for a simple and accurate method to obtain the fluorescence image without lifetime-extraction for time-resolved fluorescence imaging. An illumination source circuit for TRFI is also disclosed that shapes the excitation pulse. In one embodiment, the illumination source comprises an LED and stub line configured for generating a linear decay profile.

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Los Angeles, CA, United States of America

Maie St John