Lifescan Corporation

Tusker Medical, Inc.

Inquis Medical, Inc.

Acclarent, Inc.

Lifescan Scotland Limited

Cilag International Gmbh

Smith + Nephew

Smith & Nephew Orthopaedics Ag

Smith Nephew Asia Pacific Pte. Limited

Mahyar Zardoshti Kermani

Rohit Kulbhushan Girotra

Bernard H Andreas

Timothy J Ohara

Vahid Saadat

Eric A Goldfarb

William Jason Fox

Mojgan Saadat

Maria Teodorczyk

Neekon Saadat

Michael Pare

Scott J Baron

Nikhil Bhat

T Daniel Gross

Jeffrey Allen Walker

Mansour A Saleki

Robert Justice Shartle

Mathew D Clopp

Sherry Guo

Thomas Jetter

Klaus Neubert

Thomas M Weber

Edward Docherty

Sherry X Guo

Robert Edwin Schneider

David Elder

Andrew Lantz

Ulrich Kraft

Matthew D Clopp

Brian Domecus

John McInulty

Eric Milledge

Tyler Bennett Bigham

John Mcinulty

Rohit Girotra

Nikhil D Bhat

Described here are methods and apparatuses for removing a clot material from a patient. For example, an apparatus as described herein may include a flexible elongate body having a suction lumen, a first pair of sensors (e.g., electrodes), and a controller configured to identify a clot material based on signals from the first pair of sensors.

Methods for removing a blood clot material

Visualization during medical procedures is provided using a visualization system comprising: a control device defining an upper surface and a lower surface; a display visible through the upper surface of the control device; a handle coupled to the lower surface and extending away from the lower surface; a knob coupled to the control device, the knob configured to rotate about a rotational axis; an imaging assembly mechanically coupled to the knob and communicatively coupled to the control device, the imaging assembly configured to rotate around the rotational axis based on rotation of the knob; and the control device configured to display an image on the display, the image captured by the imaging assembly.

Systems, devices, and methods for visualization during medical procedures

Methods of making and using pharmaceutical compositions for iontophoresis that include selecting an isotonic pharmaceutical composition that has ions of active and non-active ingredients and reducing/removing the ions of the non-active ingredients from the pharmaceutical composition to produce a revised pharmaceutical composition. The revised pharmaceutical composition is thereafter utilized for iontophoresis in an iontophoresis system. During the step of performing iontophoresis with the revised pharmaceutical composition for a pre-determined dosage, ramp-up period, maximum current, overall time, etc., can be reduced, as compared to performing iontophoresis with the isotonic pharmaceutical composition to provide the pre-determined dosage.

Methods for making and using pharmaceutical compositions for iontophoresis

Described herein are methods and apparatuses for identifying a clot material in contact with a suction catheter. For example, an apparatus as described herein may include a flexible elongate body having a suction lumen, and an aspiration opening sensor comprising at least two electrodes, and a controller configured to distinguish between clot and blood based on an impedance signal between the two or more electrodes.

Apparatuses and method for determining if a catheter is engaged with a blood clot

Apparatuses and methods for distinguishing a blood clot from a vessel wall. These methods and apparatuses may include an aspiration opening into a suction lumen, an aspiration opening sensor(s) positioned at a rim of the aspiration opening, and a controller that interprets signals from the aspiration opening sensor(s) to determine when the aspiration opening is contacting a clot material or a vessel when a force is applied.

Apparatuses and methods for distinguishing clot material from vessel wall

Various systems and methods provide iontophoretic delivery of anesthesia at a patient's tympanic membrane. At least one example is a method including: performing iontophoresis within a first ear canal by driving, by a control unit, a DC signal to an electrode of a first iontophoresis device positioned within the first ear canal, the electrode at least partially submerged within an iontophoresis fluid within the first ear canal; measuring, by the control unit, a mixed capacitance associated with the electrode by driving a first AC signal having a first frequency to the electrode; and determining, based on a change in the mixed capacitance, that an air bubble is present in the iontophoresis fluid.

System and method for providing iontophoresis at tympanic membrane

Systems, apparatuses, and methods are described for providing visualization inside an ear of a subject before, during, or after an otologic procedure. An apparatus () includes a light source (), a sensor (), a processor (), and a display (). The light source () can be configured to provide incident light to a target area (TM), and the sensor () can be configured to capture reflected light from the target area (TM) to generate image data based on the reflected light. The processor () can process the image data to produce an image of the target area (TM), and the display () can display the image of the target area (TM).

Visualization devices and methods for otologic procedures

Systems, apparatus, and methods are described for delivering a therapeutic substance to a target area within or proximate to a nasal cavity of a subject, including a reservoir configured to contain the therapeutic substance and a delivery interface by which the therapeutic substance is delivered to the target area. In some embodiments, systems, apparatus, and methods described herein can deliver a therapeutic substance using iontophoresis and/or electroosmosis.

Systems, apparatus, and methods for delivery of therapeutic substance to nasal cavity

Systems, apparatus, and methods are described for transporting and delivering a therapeutic substance to an ear of a subject, including a tubular element () configured for deployment in a tympanic membrane (TM) and a fluid transport element (). The fluid transport element can be configured to transport the therapeutic substance from a proximal side to a distal side of the tubular element. Systems, apparatus, and methods further can include a fluid dispenser including a reservoir configured to contain a therapeutic substance, and a tubular element defining a lumen in fluid communication with an outlet in which the lumen and the outlet are configured to deliver the therapeutic substance from the reservoir to a region proximal to the tympanic membrane. Systems, apparatus, and methods further can include an electrode device.

Systems, apparatus, and methods for transport and delivery of therapeutic substance to middle ear

Described herein are methods and apparatuses for detecting an obstructive material within a lumen of an aspiration catheter using one or more sensors with the lumen of the suction catheter to prevent excess blood loss and improve operation of the apparatus.

Apparatuses and methods for controlling removal of obstructive material

Described here are methods and apparatuses for tracking a clot material within a lumen of a suction catheter. For example, an apparatus as described herein may include a flexible elongate body having a suction lumen, a first pair of electrodes within the suction lumen, a second pair of electrodes proximal to the first pair of electrodes, and a controller configured to track a clot material within the suction lumen based on signals from the first pair of electrodes and the second pair of electrodes.

Apparatuses and methods for tracking obstructive material within a suction catheter

Various systems and methods provide iontophoretic delivery of anesthesia at a patient's tympanic membrane. Some implementations provide channel switching enabling a single current sink to pull current through two electrodes in an alternating fashion based on clock pulses. The iontophoretic delivery of anesthesia may be driven by an AC modulated current. Some implementations provide for continuous flow of fresh iontophoresis fluid to the ear canal during iontophoresis. The fluid flows from a source reservoir into the cavity between the tympanic membrane and a plug, and then drains out of the cavity to a reservoir. An iontophoresis system may also detect capacitance between an anode electrode and an auxiliary electrode in a patient's ear canal, watching for reduced capacitance to indicate presence of a bubble in the iontophoresis fluid.

A tympanostomy tube delivery device comprises a shaft assembly, a pressure equalization tube, and a sensor. The shaft assembly comprises a cannula and a pusher operable to translate relative to the cannula. The pressure equalization tube is positioned within the shaft assembly. The pusher is operable to drive the pressure equalization tube out of the shaft assembly. The sensor is operable to detect a physical parameter associated with engagement between the distal end of the shaft assembly and a tympanic membrane. A controller may activate a feedback device to inform an operator that the distal end of the shaft assembly has achieved suitable apposition with the tympanic membrane, based on information from the sensor.

Features to improve and sense tympanic membrane apposition by tympanostomy tube delivery instrument

An apparatus includes a power source, a pulse generator, a light source, a guidewire, an optical fiber, and a connector. The pulse generator is in electrical communication with the power source. The pulse generator is also capable of generating an electric pulse. The light source is in electrical communication with the pulse generator in such a way that the light source turns on and off in response to the electric pulse received from the pulse generator. The guidewire includes a proximal end and a distal end. The optical fiber extends through the guidewire from the proximal end of the guidewire towards the distal end of the guidewire. The connector couples with the guidewire while allowing the light source to communicate with the optical fiber.

Apparatus and method to illuminate and orient guidewire

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Pleasanton, CA, United States of America

Mahyar Zardoshti Kermani