Postech Foundation

Postech Academy-industry Foundation

Posco and Postech Foundation

Mahn-Joo Kim

Jaiwook Park

Jun Ho Choi

Yangsoo Ahn

Won-Hee Kim

Jae Kwan Lee

Kiwon Han

Yoon Kyung Choi

The present invention relates to a method of preparing optically active amines and chiral amines prepared thereby. The method includes reacting an amine compound, a metal catalyst, a biocatalyst including a lipase, and an acyl donor compound in an organic solvent to obtain a chiral amide compound, and then hydrolyzing the chiral amide compound to obtain a chiral amine.

Method for preparing optically active amines

A chiral compound, particularly a chiral secondary alcohol, can be efficiently resolved under a mild condition by acylation with an alkenyl acetate in the presence of a novel aminocyclopentadienyl ruthenium complex, an enzyme catalyst, and a base.

Resolution of chiral compounds using aminocyclopentadienyl ruthenium catalysts

Disclosed is an ionic liquid-coated enzyme, wherein the ionic liquid is an organic salt which presents as a liquid phase at a temperature of about 150&#xb0; C. or below. The ionic liquid-coated enzyme according to the present invention remarkably improves enzyme functions, such as enantioselectivity and stability, when the enzyme which may be lipase is coated with an ionic liquid. Further, even in the case of when the ionic liquid-coated enzyme is reused, the enantiomeric excess, enantioselectivity, and activity are not degenerated. The coated enzyme is usable as a catalyst for providing a chiral intermediate required in the synthesis of chiral pesticides, medicines, natural chemicals, and so on.

Enzymes coated with ionic liquid

Novel aminocyclopentadienyl ruthenium complex is useful as a catalyst in the racemization of a chiral compound.

Growing community of inventors

Pohang, South Korea

Mahn-Joo Kim