Wyeth

Pfizer Corporation

Mahmut Levent

Mousumi Ghosh

Panolil C Raveendranath

Ronald Stanley Michalak

Christoph Martin Dehnhardt

Michael William Winkley

Charles Guinosso

Frederick J Vyverberg

Ara R Boyajian

Michel Cantin

Alan Stockton

Yanzhong Wu

Jianxin Ren

Karen Sutherland

Christoph Dehnhardt

Ronald S Michalak

The present invention provides a compound of formula 1: wherein Ris CF, Ris H' Ris H.

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The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: wherein R, R, R, Rand Rare defined as described herein. The compound of formula 4 is then converted to the compound of formula 1. The invention further comprises compounds of formulas 3 and 4 and methods for making compounds of formulas 3 and 4.

A process for making a compound of formula I and intermediate compounds thereof, wherein Ris CN, F or Cl; Ris H or Br; and Rand Rare each independently H or F. The compounds of formula I are useful in the treatment of chronic inflammatory diseases, such as rheumatoid arthritis.

Process for the synthesis of 3-(3-fluoro-4-hydroxyphenyl)-7-hydroxynaphthonitrile

The present invention provides processes for the preparation of arylalkylsulfonyl halides and heteroarylalkylsufonyl halides of Formula I: Ar&#x2014;R&#x2014;SO&#x2014;X, that are useful as intermediates in the preparation of pharmaceuticals.

Processes for the preparation of aryl- and heteroaryl-alkylsulfonyl halides

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Bloomfield, NJ, United States of America

Mahmut Levent