Alza Corporation

Emergex USA Corporation

Zosano Pharma Corporation

Zp Opco, Inc.

Mahmoud Ameri

Peter E Daddona

Michel J N Cormier

Yuh-Fun Maa

Yi Ao

Donald Kellerman

Marika Kamberi

Scott Sellers

Wei-Qi Lin

WeiQi Lin

Marika Kamberl

Peter C Schmidt

Michel JN Cormier

Compositions, devices and methods employing therapeutic concentrations of a triptan for treatment of migraine are described. Also described are methods and apparatuses for delivery of zolmitriptan for achieving a Tas quick as 2 minutes and not later than 30 minutes in the majority of subjects.

Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines

Compositions, devices and methods employing therapeutic concentrations of a triptan for treatment of migraine are described. Also described are methods for treating migraine by administering zolmitriptan using an adhesive dermally-applied microarray (ADAM) resulting in rapid and durable pain relief, pain freedom and reduction in most bothersome migraine-associated symptoms (MBS), or a combination thereof.

Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches

Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents.

Stable therapeutic formulations

There is provided glucagon formulations suitable for preparing coatings on microneedle patches for the transdermal delivery of glucagon. The coated patches may be used for the treatment of low blood sugar in diabetic patients. Also provided are glucagon loaded patches, methods for their preparation, and methods of their use.

Stable glucagon peptide formulations

An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.

Apparatus and method for transdermal delivery of parathyroid hormone agents

The invention provides for a formulation for coating one or more microprojections which reduces or minimizes the loss of counterions from the coating in order to achieve a pH-stabilized formulation.

Formulations for coated microprojections containing non-volatile counterions

Apparatus for transdermal delivery of parathyroid hormone agents

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Fremont, CA, United States of America

Mahmoud Ameri