King Abdulaziz University

Mahmoud A Elfaky

Abdelsattar Mansour Omar

Moustafa Elsayed El-Araby

Maan Talaat Khayat

Ghufran A Alhowswi

Fatma M Alhaity

Muna M Albeeshy

Mohammed A Baradwan

Moustafa E El-Araby

Sameh H Soror

Chronic hepatitis C is a global health problem affecting large number of people and leads to mortalities and morbidities. In this invention, new compounds belonging to 2-substituted-1H-imidazole-4-carboxamide derivatives (Formula I) intended for use in the treatment of hepatitis C are disclosed. The compounds interfere with the important viral peptide NS4A co-enzyme function. The described art includes chemical synthesis, spectral confirmation and binding assays with NS3 protein.

2-aminomethylimidazole mimics of NS4A and their effect thereof on hepatitis C virus NS3 protease

Compounds for the chemosensitization of antibiotic resistant bacteria such as multidrug resistant (MDR)(Pa) are provided. The compounds inhibit the MDR efflux proteins and re-sensitize the bacteria towards killing by antibiotics. Thus, the compounds are used in combination with antibiotics to treat or prevent infections caused by MDR bacteria.

Chemosensitization of resistantby synthetically related compounds

Growing community of inventors

Jeddah, Saudi Arabia

Mahmoud A Elfaky