Augusta University Research Institute, Inc.

Mahmood Mozaffari

Babak Baban

Rafik Abdelsayed

Jun Yao Liu

Compositions and methods for treating hair loss are provided. One embodiment provides a microneedle composition, which when administered to the skin of a subject promotes hair growth. The microneedle compositions include an effective amount of glucocorticoid-induced leucine zipper (GILZ) protein having an amino acid sequence that has 99 or 100% identity to SEQ ID NO: 1, or fragment thereof to promote hair growth when administered to the skin of the subject and a bioerodible, biodegradable, or biosorbable polymer, wherein the composition is formulated as bioerodible, biodegradable, or bioabsorbable microneedles. In one embodiment the GILZ protein or fragment thereof is conjugated to a cell penetrating peptide. The cell penetrating peptide can be TAT GRKKRRQRRRPQ (SEQ ID NO:4) or a variant thereof.

Compositions and methods for promoting hair growth

Glucocorticoid-induced leucine zipper protein (GILZ) peptide compositions and their methods of use in wound healing are disclosed herein. An exemplary GILZ peptide composition includes a GILZ fusion protein. The GILZ peptide compositions can be administered topically to wounds, for example in the form of a cream, ointment, or lotion. The GILZ peptide compositions can be used to treat acute wounds, induce wound healing in chronic wounds, and reduce scar formation.

GILZ formulations for wound healing

Methods for detection and diagnosis of Sj&#xf6;gren's Syndrome in a subject, determining the stage or progression of Sj&#xf6;gren's Syndrome in a subject, determining the effectiveness of a treatment for Sj&#xf6;gren's Syndrome, and selecting a subject for treatment for Sj&#xf6;gren's Syndrome are disclosed. The methods typically include measuring the level of one or more Sj&#xf6;gren's Syndrome biomarkers in a biological sample obtained from a subject. Biomarkers for Sj&#xf6;gren's Syndrome include, but are not limited to, GADD153 and Del-1.

Growing community of inventors

Martinez, GA, United States of America

Mahmood Mozaffari