Taro Pharmaceuticals Inc.

Aquinox Pharmaceuticals (canada) Inc.

Mahesh Narayan Keregadde

Curtis Harwig

Jeyaprakashnarayanan Seenisamy

Jeremy D Pettigrew

Jennifer Cross

Karthikeyan Iyanar

Lakshindra Chetia

Samir Satish Kher

Compounds of formula (1): wherein, R, R, R, R, Rand Rare described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.

Indene derivatives useful in treating pain and inflammation

Compounds of formula (I) wherein, R, R, R, R, R4b and Rare described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain. 

Compounds of formula (I): wherein, R, R, R, R, Rand Rare described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain. 

This invention is directed to methods of preparing AQX-1125 having the formula:  This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.

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Vancouver, Canada

Mahesh Narayan Keregadde