Bristol-myers Squibb Compnay

Bristol-myers Company

Bristol-myers Squibb

Briston-myers Company

Mahesh K Patell

Thomas M Tencza

Michael Corbo

F Henry Merkle

Jatin Desai

Ronald Warrick

Gerard Frunzi

There is provided a coating composition that masks the undesirable taste of a pharmaceutically active ingredient, i.e. drug or medicine, that is taken orally. The coating composition is comprised of dimethylaminoethyl methacrylate and neutral methacrylic acid ester, a cellulose ester polymer, and an alkaline modifier.

Taste masking coating composition

There is provided a coating composition that masks the undesirable taste of a pharmaceutically active ingredient, i.e. drug or medicine, that is consumed orally. The coating composition has polyvinyl acetate, and a dimethylaminoethyl methacrylate and neutral methacrylic acid ester. Optionally, an alkaline modifier may be included in the coating composition to enhance release of the active ingredient.

Gelatin coated pharmaceutical dosage units containing, for example, analgesic compounds, such as aspirin, stabilized with a proteolytic enzyme, such as pepsin, are described.

Stable gelatin coated aspirin tablets

A tamper-resistant dosage form capsule for the oral administration of therapeutic agents comprises a two-part capsule which is shrunk around a caplet so that the outer wall of the caplet is bound to the inner walls of both parts of the capsule. The caplet is placed into the capsule, and the dosage form is then subjected to relatively high humidity and temperature conditions, followed by drying the dosage form in a lower humidity environment, so that the capsule is shrunk to conform to the contours of the caplet and both parts of the capsule are bonded to the caplet.

Capsule and caplet combination

A stabilized enteric coated aspirin granule product prepared by commingling the enteric coated aspirin granules with glutamic acid hydrochloride.

Stabilized enteric coated aspirin granules and process for preparation

The unpleasant taste of ibuprofen or other bad-tasting pharmaceuticals can be mediated via wet granulation using certain taste masking agents.

Taste-masking pharmaceutical agents

Stabilized enteric coated aspirin granules and process of preparation

A capsule shaped tablet containing a pharmaceutically active ingredient in which the tablet has a cap portion and a body portion physically bound to each other; the cap portion having a larger outside diameter than the body; the tablet may be provided with a coating of a film forming polymer to simulate a hard gelatin capsule dosage form.

Capsule shaped tablets

An enteric coated tablet and process is described in which a core tablet of a pharmaceutically active ingredient is provided with an enteric coating layer of a film forming enteric polymer and an overcoat layer of non-enteric film forming polymer; optionally, the tablet may also be provided with the non-enteric undercoat layer of a film forming polymer.

Enteric coated tablet and process for making

An analgesic capsule containing asprin and APAP. The aspirin is in the form of an enteric coated granule, and the APAP is present in powder form.

Growing community of inventors

Edison, NJ, United States of America

Mahesh K Patell