Schering Corporation

Harbor Branch Oceanographic Institution, Inc.

Mahesh G Patel

Ann C Horan

Joseph A Marquez

Vincent P Gullo

Marvin J Weinstein

Min Chu

Gerald H Wagman

Vinod R Hegde

Raymond T Testa

George H Miller

Jay A Waitz

Stephen J Coval

David Taplin

Shirley A Pomponi

J Allan Waitz

Roberta S Hare

David Loebenberg

Raymond Cooper

Joseph Terracciano

Heewon Y Kwon

Ronald A Mierzwa

Ingrid-Agneta Gunnarsson

Frank A Gentile

James A Matson

Jerzy Golik

Imbi Truumees

Jerome Schwartz

John K Jenkins

Manohar G Kalyanpur

Richard W Vaughan

Shirley A Pompni

Raymond F Yarborough

James B Morton

Vinod R Hedge

Ellen B Barrabee

Arthur H King

Novel tetramic acid-type compounds isolated from a CCR-5 active complex produced by fermentation under controlled conditions of a biologically pure culture of the microorganism, Kunze SCH 1705, ATCC 74489., pharmaceutical compositions containing the compounds and the use of the CCR-5 antagonist compounds and compositions to treat HIV-1 infections in humans are disclosed.

Chemokine receptor antagonists

Three novel macrolactam monosaccharides isolated from an antimicrobial complex 510 produced in fermentation under controlled conditions using a biologically pure culture of the microorganism Actinomadura fulva subsp. uruguayensis ATCC 53713.

Actinomadura fulva subsp uruguayensis and antimicrobial complex and

A novel macrolactam monosaccharide isolated from an antimicrobial complex 517 produced in fermentation under controlled conditions using a biologically pure culture of the microorganism Actinomadura vulgaris subsp. vulgaris ATCC 53748.

Actinomadura vulgaris subsp vulgaris and antimicrobial complex and

Orthosomycins have been isolated from the fermentation broth of the microorganism Micromonospora Carbonacea var Africana designated SCC 2146. These compounds are antibacterial agents. Compositions and methods for treating bacterial infections are also described.

Orthosomycins from micromonospora carbonacae

An aqueous pharmaceutical composition comprising a lipophilic oligosaccharide antibiotic salt, e.g., the N-methylglucamine salt of the everninomicin-type antibiotic of Formula III together with a binding agent such as human serum albumin or recombinant human albumin and a tonicity agent such as mannitol, is disclosed.

Lipophilic oligosaccharide antibiotic compositions

Lipophilic oligosaccharide antibiotic salt compositions

N-alkanoyl derivatives of staurospodne represented by the formula I ##STR1## wherein R.sub.a and R.sub.b are each H or ##STR2## wherein R.sub.1 and R.sub.2 are independently H or --OH or --OCH.sub.3 and R.sub.3 is OH, NHCH.sub.3, NCH COCH.sub.3 or NHCOCH.sub.3 and R.sub.4 is OH or H and, stereochemical isomers thereof with the provisos that (1) when R.sub.a and R.sub.b .dbd.A, and R.sub.1.dbd.H.sub.2 or OH R.sub.3 is not NHCH.sub.3 ; (2) when R.sub.a and R.sub.b.dbd. B, then R.sub.1 .dbd.R.sub.4 .dbd.OH or R.sub.1 .dbd.R.sub.4 .dbd.H; (3) when R.sub.a .dbd.R.sub.b .dbd.H R.sub.1 .dbd.--OCH.sub.3, and (4) when R.sub.a and R.sub.b .dbd.A, and R.sub.1 .dbd.H and R.sub.2 .dbd.OCH.sub.3, then R3 is not and ##STR3## pharmaceutical compositions thereof useful for inhibiting myosin light chain kinase, protein kinase C or tumor cell proliferation as well as producing an antihypertensive effect and an anti-inflammatory effect in warm-blood animals such as man are disclosed.

Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov

Compounds of the formulas: ##STR1## or pharmaceutically acceptable salts thereof. These compounds are obtainable by cultivation of a pure culture of Actinoplanes sp. SCC2314, ATCC 55600. These compounds are useful as antifungal agents.

Antifungal compounds

A method of treating mammals infected with HIV-1, or AIDS by administering a therapeutically effective amount of a compound represented by formula I ##STR1## or a pharmaceutically acceptable salt or ester thereof or stereoisomer thereof and pharmaceutical compositions containing it are disclosed.

Method and composition for treating HIV-type 1 infections

Compounds of the formula: ##STR1## wherein a is a single bond and b is a double bond; or a is a double bond and b is a single bond; and enantiomers thereof; or a pharmaceutically acceptable salt thereof are described. These compounds can improve lipoprotein profile of dyslipidemic patients and generate an anti-atherogenic lipoprotein profile of normolipidemic individuals. In addition, inhibition of CETP activity may be useful as antifertility agents.

Anti-dyslipidemic agents

Two novel glycosides of 3'-deoxyaquayamycin isolated from an antimicrobial complex produced in fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces sp. SCC 2136, ATCC 55186 are disclosed.

Glycosides of 3'-deoxyaquayamycin antibiotics

A method for treating airway congestion which comprises administering an effective amount of the compound of formula II which follows ##STR1## or a pharmaceutically acceptable salt thereof.

Method for treating airway congestion

Novel macrocyclic lactone antibacterials isolated from a culture containing the microorganism S. aerocolongenes sub sp. antibiotica SCC 1886, ATTC 55003 and their use for treating and/or preventing antibacterial infections, especially Chlamydia infections are disclosed.

Macrocyclic lactone antibacterial antibiotic compounds

Four bicyclic terpenes isolated from a culture broth of Phoma sp SCF0592, ATCC 74077, pharmaceutical compositions containing them and their use as PAF antagonists to treat allergic and inflammatory diseases are disclosed.

Bicyclic diterpene PAF antagonist compounds

The compound of the formula ##STR1## is described. This compound is active in an H.sub.3 receptor assay and is an H.sub.3 antagonist. Accordingly, the compound of formula I is useful in the treatment of diseases and conditions such as asthma, rhinitis, airway congestion, inflammation, cardiac arrhythmias, hypertension, hyper and hypo motility and acid secretion of the gastrointestinal tract, hypo and hyper activity of the central nervous system (CNS), migraine, and glaucoma.

Growing community of inventors

Verona, NJ, United States of America

Mahesh G Patel