Abbott Laboratories Corporation

University of Illinois

Philadelphia Health and Education Corporation

Mahendra N Deshpande

Anthony Ralph Haight

Timothy Michael Block

Howard E Morton

Yi-Yin Ku

James J Napier

Steven J Wittenberger

Jien-Heh J Tien

Steven A King

Russell Drew Cink

Daniel J Plata

David R Hill

David A Riley

Marvin Robert Leanna

Michael Rasmussen

Margaret Chi-Ping Hsu

Arthur J Cooper

Eric J Stoner

Maureen Ann McLaughlin

Elaine C Lee

Prasad S Raje

Tim Grieme

Matthew John Peterson

Robert M Moriarty

Baohua Gu

Rajendra C Shah

David Riley

Marvin R Leanna

Maureen A Mclaughlin

An anti-viral compounds effective against viruses belonging to the Flaviviridae family, wherein the anti-viral compounds are 1,5-dideoxy-1,5-imino-D-glucitol derivative compounds having the general formula (I) wherein R, R, Rand Rare the same or different and are selected from the group consisting of hydrogen, acyl, benzyl, alkyl, aryl, sulfonyl, phosphonyl, silyl, Ris at least one of alkyl or branched alkyl, heteroalkyl or aryl, R' is a bridging group selected from at least one of bicycle[2.2.1]heptyl, bicycle[3.2.1]octyl, oxa analogs, admonyl and cubyl, n&#x2032;=2-10, n&#x2033;=1-10, enantiomers and stereoisomers of said compounds and physiologically acceptable salts or solvates of said compounds, enantiomer or stereoisomer.

Iminosugar compounds with antiflavirus activity

In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2&prime;-substituted and optionally 4&Prime;-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.

Process for preparing 6-o-substituted erythromycin derivatives

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Gurnee, IL, United States of America

Mahendra N Deshpande