University of Virginia Patent Foundation

Hampton University

Other

Virginia Tech Intellectual Properties, Inc.

Allomek Therapeutics LLC

Allostem Therapeutics LLC

Mahendra Devichand Chordia

Dongfeng Pan

Tyvin A Rich

Prakash G Jagtap

John F Kadow

Timothy L MacDonald

Joel M Linden

Uday R Khire

David G Kingston

Lauren J Murphree

David George Ian Kingston

The present application provides compositions and methods for preparing and using 'heavy' nucleotide derivatives of thymidine or uridine by replacing the oxygen atom attached to one or more of positions with non-radioactive oxygen-18 (O), administering it to a subject to target a tumor including incorporation into tumor cell DNA, and then treating the tumor with proton beam therapy to transmutate theO toF, resulting in a break of the new fluorine-phosphorous bond. This chemical event destabilizes ribose-phosphate DNA back-bone and base pairing thus produce single- and double strand breaks, clusters lesions that can lead to irreparable DNA damage and enhanced tumor cell killing. The atomic, chemical, and physical aspects result in the use of lower radiation doses and significantly alter acute and late morbidity of radiotherapy. Heavy thymidine and heavy uridine derivatives labeled withO have been made and tested.

Proton activated atomic medicine

The invention pertains to compound of Formula (I) wherein X, Y, Z, R, R, R, R, A and A' are as described hereinabove. Formula (I) and (II) compounds can be used in pharmaceutical compositions, useful for the treatment of diseases. 

MEK inhibitors useful in the treatment of diseases

The present invention relates generally to a class of 2-aminothiazole derivatives which have recently been identified as allosteric enhancers of the A1? adenosine receptor. These compounds, and therapeutic compositions containing them, are useful for treating conditions in which activation of the A1? adenosine receptor would be beneficial, for example, those conditions in which stimulation of angiogenesis would improve blood flow to ischemic tissues.

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2-debenzoyl-4-deacetyl paclitaxel, antineoplastic analogs thereof and intermediates are taught, as well as the formation of the compound, analogs and intermediates. The compound, analogs and intermediates may be used to form pharmaceutical compositions having anti-neoplastic activity. Further, the compound, analogs and intermediates may be used to treat cancer when applied in an effective amount by means such as a pharmaceutical composition.

2-aroyl-4-acyl paclitaxel (Taxol) analogs

The present invention provides methods for making a novel class of 1-deoxy paclitaxel derivatives. These derivatives include 1-deoxy paclitaxel. The derivatives of the present invention are potent cytotoxic agents.

Methods for preparing 1-deoxy paclitaxels

Growing community of inventors

Charlottesville, VA, United States of America

Mahendra Devichand Chordia