Alfa Wassermann S.p.a.

Mahena Folegatti

Vincenzo Cannata

Manuela Campana

Goffredo Rosini

Giuseppe Claudio Viscomi

Paolo Righi

Paola Righi

Giuseppe Glaudio Viscomi

Disclosed are rifamycin derivatives having antibacterial activities, wherein the compounds have the following general formula: wherein:R is hydrogen or acetyl; Rand Rare independently selected from the group consisting of hydrogen, (C) alkyl, benzyloxy, mono- and di-(C) alkylamino-(C)alkyl, (C)alkoxy, (C) alkyl, hydroxy-methyl, hydroxy-(C)-alkyl, and nitro or Rand Rtaken together with two consecutive carbon atoms of the pyridine nucleus form a benzene ring optionally substituted by one or two methyl or ethyl groups and Ris hydroxyalkyl (C). In addition, processes to obtain these compounds are described.

Rifamycin derivatives

Disclosed are rifamycin derivatives having antibacterial activities, wherein the compounds have the following general formula: wherein: R is hydrogen or acetyl; Rand Rare independently selected from the group consisting of hydrogen, (C)alkyl, benzyloxy, mono- and di-(C)alkylamino-(C)alkyl, (C)alkoxy, (C)alkyl, hydroxy-methyl, hydroxy-(C)-alkyl, and nitro or Rand Rtaken together with two consecutive carbon atoms of the pyridine nucleus form a benzene ring optionally substituted by one or two methyl or ethyl groups and Ris hydroxyalkyl(C). In addition, processes to obtain these compounds are described.

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Bologna, Italy

Mahena Folegatti