Allied Bioscience, Inc.

Srfc Bio, Inc.

Maha El-Sayed

Gavri Grossman

Jie Fang

Parham Asgari

Daniel A Moros

Craig Grossman

Valerie Beck

Elias Shaheen

A method of quantifying an antimicrobial coatings using a handheld XRF analyzer is disclosed. The method provides an estimate of the expected level of antimicrobial efficacy for a thin film comprising silicon and/or titanium by obtaining aSi orTi peak intensity using XRF spectroscopy and converting the obtainedSi orTi peak intensity to the expected level of efficacy using a calibration curve. A properly calibrated handheld XRF analyzer allows a user to assess the viability of antimicrobial coatings in the field, such as in a hospital where various fomites may be coated with silane and/or titanium compositions.

Analysis of antimicrobial coatings using XRF

Aqueous antimicrobial coating compositions are disclosed comprising at least one organosilane homopolymer, present as a distribution of polymer chain lengths, and optionally at least one amine. A method of preparing an antimicrobial coating comprises coating a surface with the aqueous antimicrobial coating composition and allowing the composition to dry into a film that exhibits residual antimicrobial efficacy against microorganisms even after mechanical abrasion of the coating. The organosilane homopolymer may comprise only 3-aminopropylsilanetriol homopolymer, mixtures of 3-aminopropylsilanetriol homopolymer, 3-chloropropylsilanetriol homopolymer and 3-(trihydroxysilyl)propyl dimethyloctadecyl ammonium chloride homopolymer, or any one of various unique organosilane homopolymers having multiple amine functionality.

Antimicrobial coatings comprising organosilane homopolymers

An aqueous antimicrobial coating composition capable of forming an antimicrobial coating on a surface comprises at least two organosilanes, each of the at least two organosilanes having a structure, R&#x2014;Si(OR')wherein R=&#x2014;(CH)&#x2014;Y; Y=&#x2014;N(CH)(CH)X;&#x2014;N(CH)(CH)X;&#x2014;N(CH)(CH)X; &#x2014;Cl or &#x2014;NH; X=halide, sulfate, nitrate, phosphate, carbonate, organic sulfonate, organic carbonate, BF, or ClO; and R&#x2032;=H, methyl or ethyl, or a C-Cstraight-chained, branched or cyclic alkyl group, with the proviso that the organosilane R&#x2014;Si(OR&#x2032;)having the C-Cstraight-chained, branched or cyclic alkyl group hydrolyzes in the aqueous antimicrobial coating composition to R&#x2014;Si(OH).

Broad spectrum antimicrobial coatings comprising combinations of organosilanes

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Fremont, CA, United States of America

Maha El-Sayed