Bracco Imaging S.p.a.

Magnus Karlsson

Pernille Rose Jensen

Mathilde H Lerche

Fabio Tedoldi

Sonia Colombo Serra

Silvio Aime

Massimo Visigalli

Roberta Napolitano

Giovanni Battista Giovenzana

Luigi Miragoli

Claudia Cabella

Fulvio Uggeri

Alessandro Maiocchi

Luisa Poggi

Lara Caminiti

Luca Venturi

Marco Crosetti

Lerche H Mathilde

1-C-1,1-Bis(acetoxy(methyl))-2,2'-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent inC Magnetic Resonance diagnostic technique (C-MR) for the diagnosis of tumor.

Hyperpolarized 1-13C-1,1-bis(acetoxy(methyl))-2,2'-cyclopropane as metabolic marker for MR

The invention relates to a method of Magnetic Resonance (MR) detection, in particularC-MR detection, by using a diagnostic medium comprising a hyperpolarized ester, in particular ethyl acetoacetate. The method comprises the detection of the MR signal of a hyperpolarizedC carboxylic ester and of its respective hyperpolarized metabolite.

Hyperpolarized esters as metabolic markers in MR

Method for manufacturing a hyperpolarized amino acid, in particular glutamine, which substantially limits the formation of by-products, with respect to conventional aqueous preparations of sodium hydroxide with amino acids. The amino acid is in particular admixed with the hydroxide in the substantial absence of water and the dry mixture is dissolved in an anhydrous solvent in the presence of a polarizing agent. The obtained mixture is then subjected to a DNP process and can be used in metabolic MR imaging.

Hyperpolarized amino acids

The present invention generally relates to a composition comprising acetic anhydride, a DNP agent and a gadolinium complex and its use for the preparation of hyperpolarised imaging agent for MR diagnostic analysis.

Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis

The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.

Process for preparing hyperpolarized substrates and method for MRI

The present invention relates to a process for the preparation of aqueous solutions of hyperpolarized carboxylic organic acids ready for use in in-vivo MR diagnostic imaging, and the use of the corresponding anhydrides or esters as glass-forming agents.

Process for the preparation of hyperpolarized derivatives for use in MRI analysis

New radical compounds, useful in the field of MRI imaging of formula (I). The radical compounds are in particular new triarylmethyl ('trityl') radicals which can be used as polarizing agents for polarizing a molecule in the DNP process. 

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Malmo, Sweden

Magnus Karlsson