Biovitrum Ab

Biovitrum Ab (publ)

Other

Medigene Ag

Proximagen Limited

Magnus Cernerud

Alexander Paptchikhine

Helena Lundström

Margit Pelcman

Alf Nygren

Emma Andersson

Claes Löfström

Tom Fleck

Bruce Fleck, Legal Representative

Björn M Nilsson

Markus Thor

Kristina Berntsson

The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R-Rare each independently selected from the group consisting of hydrogen, halogen, C-C-alkyl, C-C-alkoxy, and di-C-C-alkylamino-C-C-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.

Pharmaceutical composition containing (2R)-methyl-1-3-[2-(3-pyridinyloxy)ethoxy]-2-pyrazinylpiperazine L-malate for treatment of serotonin-related diseases

(2R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine and salts thereof

Malate salt of (2R)-methyl-1-{3-[2-(3-pyridinyloxy)ethoxy]-2-pyrazinyl}piperazine

Stable acid addition salts of certain 2,3-disubstituted pyrazine compounds that are selective for the 5-HT2c receptor and therapeutically active in the central nervous system are described.

Phosphoric acid addition salt of (2R)-1-[3-(2-{[2-(2-dimethylaminoethoxy)-3-pyridinyl]oxy}-ethoxy)-2-pyrazinyl]-2-methylpiperazine

Compounds of the general formula (I):  Further included are pharmaceutical compositions comprising the compounds, processes for their preparation, as well as the use of the compounds for the preparation of a medicament for the treatment of 5-HTreceptor-related disorders or medical conditions.

Amino-substituted 1H-pyrazin-2-ones and 1H-quinoxalin-2-ones

The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general formula (I): wherein HA is a pharmaceutically acceptable acid and R&#x2013;Rare each independently selected from the group consisting of hydrogen, halogen, C&#x2013;C-alkyl, C&#x2013;C-alkoxy, and di-C&#x2013;C-alkylamino-C&#x2013;C-alkoxy. The invention also relates to the use of said compound to manufacture a medicament for the treatment of a serotonin-related disorder.

Process for the preparation of stable acid addition salt of 2,3-disubstituted pyrazine compounds

The invention relates to processes for preparing oxiranecarboxylic acids and derivatives thereof, in particular to processes which proceed under stereochemical control of the reaction steps, to the oxiranecarboxylic acids prepared according to the invention and derivatives thereof and to their use in pharmaceutical compositions, in particular for treating hyperlipaemia.

Methods for producing oxirane carboxylic acids and derivatives thereof

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Stockholm, Sweden

Magnus Cernerud