Georgia State University Research Foundation, Inc.

Beth Israel Deaconess Medical Center, Inc.

Emory University

Lahjavida, LLC

Maged M Henary

John V Frangioni

Gabor Patonay

James J Krutak

Hak Soo Choi

W David Wilson

Lyle D Small

Leland W K Chung

Lucjan Strekowski

Ruoxiang Wang

Haiyen E Zhau

Guodong Zhu

Xiaojian Yang

Chunmeng Shi

Jordan L Malray

This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.

Cyanine-containing compounds for cancer imaging and treatment

Cyanines which selectively bind to G-quadruplex DNA complexes, particularly quadruplexes expressed in cancer cells, and methods of making and using thereof are described herein. The cyanine can be a symmetrical or unsymmetrical streptocyanine, hemicyanine, closed chain cyanine, or combinations thereof. The cyanine is preferably substituted with one or more groups that minimize or prevent aggregation of the cyanine and/or inhibit binding of the cyanine to duplex DNA. One or more of the cyanines can be formulated with one or more pharmaceutical excipients and/or carrier to prepare pharmaceutical compositions suitable for administration to a patient, particular a human patient. The compounds and compositions described herein can be used to treat diseases or disorders characterized by the expression of G-quadruplex DNA, such as cancer.

Carbocyanines for G-quadruplex DNA stabilization and telomerase inhibition

The instant invention provides near-infrared fluorescent biological contrast agents and methods of using them.

Near-infrared fluorescent contrast bioimaging agents and methods of use thereof

The instant invention provides near-infrared fluorescent nerve contrast agents and methods of using them.

Near-infrared fluorescent nerve contrast agents and methods of use thereof

The present invention relates to compositions for and methods of optically imaging tissues or cells using imaging agents having desirable in vivo properties that result in improved signal-to-background ratio.

Charge-balanced imaging agents

Provided herein are heterocyclic near infrared compounds, including near IR compounds defined by Formulae I-V described herein. The near infrared compounds can include a cyanine group, a phthalocyanine group, a naphthalocyanine group, a squaraine group, a carbocyanine group, or a combination thereof. In some embodiments, the near infrared compound can be charged. In some embodiments, the near infrared compound can comprise a cationic group. Compositions comprising the near infrared compounds are also disclosed. In some embodiments, the composition can contain the near infrared compound, a polymer, and an acceptable carrier. In some embodiments, the polymer can include an anionic group. The compositions can be used as a coating for marking a surface, such as an ink. The compositions can also be used on articles for detecting, identifying, or authenticating the article. Methods of making the compositions described herein are also disclosed.

Near infrared absorbing fluorescent compositions

This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Au&#x2014;[CH(CH)CH&#x2014;(OCHCH)O]COCHCH-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.

Method and dyes for detecting and destroying cancer cells

Charged-balanced imaging agents

The present invention relates to compositions and methods of optically imaging tissues or cells using imaging agents have in vivo properties that result in signal-to-background ratios of at least about 1:1. TL is a targeting ligand and n is &#x2212;1, 0 or +1. 

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Lawrenceville, GA, United States of America

Maged M Henary