Hydra Biosciences, Inc.

Children's Medical Center Corporation

Other

Eli Lilly and Company

Magdalene M Moran

Jayhong A Chong

Christopher Fanger

Xiaoguang Zhen

Glenn R Larsen

Amy Ripka

Manfred Weigele

Dennis John Underwood

Josh Mandel-Brehm

Howard P Ng

David Clapham

Ian S Ramsey

William C Lumma

Colleen McNamara

Peter C Meltzer

Anu Mahadevan

Timothy Strassmaier

Elisha Singer

Colleen Mcnamara

Steven P Adams

Neil Hayward

Donato Del Camino

Howard Ng

The present application relates to compounds and methods for treating pain, incontinence and other conditions.

Methods and compositions for treating pain

Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.

Methods and compositions for treating anxiety

The invention provides novel compositions and compounds that inhibit CatSper channel activity, that preferentially inhibits sperm hyperactivity over sperm motility, or both. The compounds of the invention are useful as contraceptive agents that may be adminstered to males, females, or concurrently to both sexual partners. The invention further provides methods of conducting drug discovery business and of conducting a reproductive medicine business. The invention also provides methods of identifying compounds that modulate sperm hypermotility.

Modulators of sperm hypermotility and uses thereof

The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.

Compounds for modulating TRPV3 function

Provided are methods for preventing and treating injuries caused by exposure to biological warfare agents. The methods include administering to a subject in need thereof an effective amount of a TRPA1 antagonist or a pharmaceutically acceptable salt thereof. In an embodiment the TRPA1 antagonist is selected from the group consisting of compounds of formula I and compounds of formula II as described herein.

Use of TRPA1 antagonists to prevent or treat infections caused by biological-warfare agents

Compounds of modulating TRPV3 function

Nucleic acid and protein sequences relating to a proton channel (Hv1) are disclosed. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the Hv1 gene and protein are disclosed. Also provided are methods of identifying modulators of Hv1 activity, methods of geno typing subjects with respect to Hv1, and methods of diagnosing and treating Hv1-mediated disorders.

Methods of using voltage-gated Hv1 proton channels to detect changes in intracellular pH

Modulators of sperm hypermobility and uses thereof

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper3) are disclosed. The CatSper3 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper3 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper3 activity, methods of genotyping subjects with respect to CatSper3, and methods of diagnosing and treating CatSper3-mediated disorders, including infertility. Related business methods are also disclosed.

Sperm-specific cation channel, CATSPER3, and uses therefor

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper4 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper4 activity, methods of genotyping subjects with respect to CatSper4, and methods of diagnosing and treating CatSper4-mediated disorders, including infertility. Related business methods are also disclosed.

Sperm-specific cation channel, CatSper4, and uses therefor

The present application relates to compounds of Formula I as defined herein, and methods for treating pain and other conditions related to TRPV3.

Substituted pyrimido 4.5-d pyrimidin-4-one compounds for modulating TRPV3 function

Growing community of inventors

Brookline, MA, United States of America

Magdalene M Moran