Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-La Roche Ag

Magdalena Swiatek-de Lange

Johann Karl

Herbert Andres

Wolfgang Rollinger

Ralf Roeddiger

Ursula Kunert

Nina Meissler

David Morgenstern

Marion Niessner

Christoph Ehret

An in vitro method is disclosed for detecting an antibody to p53 (anti-p53 antibody) in a sample, the method comprising: incubating a sample to be analyzed with a p53 capture antigen and a p53 detection antigen, whereby a complex comprising the p53 capture antigen, the anti-p53 antibody and the p53 detection antigen is formed, separating the complex formed from unbound detection antigen and measuring the complex obtained via the detection antigen comprised therein, thereby detecting the anti-p53 antibody comprised in the sample.

Detection of anti-p53 antibodies

Described is a method aiding in the assessment of the presence of cancer. The method uses the soluble DPPIV/seprase protein complex (DPPIV/seprase) as a universal marker of different cancer types. Measurement of DPPIV/seprase complex can, e.g., be used in the early detection or diagnosis of cancer or in the surveillance of patients who undergo surgery.

Use of DPPIV/seprase as a marker for cancer

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Penzberg, Germany

Magdalena Swiatek-de Lange