Sanofi

The Salk Institute for Biological Studies

Aventis Pharma Deutschland, Gmbh

Sanofi-a Ventis Deutschland Gmbh

Magda Stankova

Jacques Mauger

Fahad A Al-Obeidi

Tony Hunter

Robert Alan Binnie

Jill Meisenhelder

Stephen Rush Fuhs

Gary A Flynn

Hans Ulrich Stilz

Martin Gerl

Robert A Binne

Robert A Binnie

A peptide is disclosed of the general structure: Z&#x2014;W&#x2014;Y, wherein Z and Y are independently a one to eight amino acid sequence wherein the amino acids are selected from glycine and alanine and W is a non-hydrolyzable pHis analogue. Such peptides can be used to produce sequence-independent anti-phosphohistidine antibodies. Also provided are antibodies that specifically bind to a peptide comprising a phosphohistidine (or a non-hydrolyzable pHis analogue) but fail to specifically bind to an identical peptide containing histidine instead of phosphohistidine.

Compositions and methods for analyzing histidine phosphorylation

Isolated monoclonal antibodies and or antigen binding fragments thereof are disclosed herein that specifically bind polypeptides comprising a histidine phosphorylated at N3 (3-pHis). Nucleic acids encoding these antibodies, vectors including these nucleic acids, and host cells transformed with these vectors and nucleic acids are also disclosed. Methods are also disclosed for using these antibodies, such as for detection of polypeptides comprising a histidine phosphorylated at N3 (3-pHis). In some embodiments, the methods can be used to investigate signal transduction pathways.

Generation and use of polyclonal and monoclonal antibodies specific for 3-phosphohistidine

Low molecular weight peptide derivatives which are able to act as inhibitors of the interaction between laminin and nidogen (laminin/nidogen interaction), a process for their preparation, pharmaceutical compositions prepared therefrom and their use for preparing pharmaceuticals and for identifying inhibitors of the laminin/nidogen interaction.

Low molecular weight peptide derivatives as inhibitors of the laminin/nidogen interaction

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Magda Stankova