Novo Nordisk A/s

Novozymes A/s

Novo Nordisk Pharmaceuticals, Inc.

Novo Nordisk Healthcare Ag

Magali Zundel

Shamkant Anant Patkar

Bernd Peschke

Soren Ebdrup

Heinz-Josef Deussen

Carsten Behrens

Nils Langeland Johansen

Kjeld Madsen

Lars Thim

Peter Rahbek Ostergaard

Carsten Mailand Hjort

Niels Christian Kaarsholm

Jens Buchardt

Florencio Zaragoza Dörwald

Susanne Bang

Soren Christensen

Birgitte Koch Michelsen

Peter Thygesen

Anette Sams Nielsen

Ditte Maria Karpf

Niels W Nils Langeland Johansen

The present invention relates to conjugated Factor VIII variants. The present invention in particular relates to conjugated FVIII variants comprising different polymeric groups as well as use thereof.

Conjugated FVIII variants

The present invention relates to novel human glucagon-like peptide-2 (GLP-2) peptides and human glucagon-like peptide-2 derivatives which have a protracted profile of action as well as polynucleotide constructs encoding such peptides, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.

GLP-2 compounds, formulations, and uses thereof

An esterase isolated fromis capable of stereoselective hydrolysis of chiral esters and also has arylesterase activity (EC 3.1.1.2) and feruloyl esterase activity (EC 3.1.1.73). The esterase has only a limited homology to known amino acid sequences.

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The present invention relates to a process comprising hydrolysis or trans esterification of one of the two enantiomeric forms of a racemic or enantiomerically enriched ester of formula I or IV by a higher rate than the other by an enzyme to give an ester and a acid (III) or two different esters (V) and (VI) with different R groups both with increased enantiomeric purity and a esterification process of a racemic or enantiomerically enriched acid (VII) by an enzyme to give an ester and an acid both with increased enantiomeric purity.

Process for the preparation of substituted 3-phenyl-propanoic acid esters and substituted 3-phenyl-propanoic acids

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Soborg, Denmark

Magali Zundel