Centre National De La Recherche Scientifique

Universitè De Montpellier

University of California

Institut National De La Sante Et De La Recherche Medicale

Institut Curie

Université Montpellier 2 Sciences Et Techniques

Ecole Nationale Superieure De Chimie De Montpellier

Nanomedsyn

Universite De Montpellier 2 Sciences Et Techniques

Université Mouloud Mammeri

Inserm (institut National De La Sante Et De La Recherche Medicale)

Université Montpellier II

Magali Gary-Bobo

Marcel Garcia

Alain Morere

Jean-Olivier Durand

Marie Maynadier

Michael J Sailor

Frederique Cunin

Jean Olivier Durand

Martine Cerutti

Philippe Maillard

Ilaria Basile

Laurence Raehm

Khaled El Cheikh

David Brevet

Ouahiba Hocine

Jimenez Chiara Mauriello

Monique Smaïhi

Sebastien Richeter

Emilie Secret

Philippe Nirde

Monique Smaiehi

The present invention relates to mesoporous organosilica nanoparticles, the method of preparation thereof, and uses of the same in treatment by means of photodynamic therapy or in imaging.

Mesoporous organosilica nanoparticles, production method thereof and uses of same

Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (&#x3e;600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle.

Functionalized porous silicon nanoparticles and use thereof in photodynamic therapy

The invention relates to conjugates of products of interest including glycoproteins, nanoparticles, and imaging agents and of compounds of the general formula (1): that target the cation-independent mannose 6-phosphate receptor with a high affinity. The invention also relates to their applications, for instance in enzyme replacement therapies.

Compounds targeting the cation-independent mannose 6-phosphate receptor

Nanovectors are disclosed that make it possible to simultaneously target, image, and treat cancerous cells using photodynamic therapy. Also disclosed are novel molecules (I) derived from porphyrins, silica-based nanoparticles comprising the same, and their use in photodynamic therapy. 

Metalloporphyrin derivatives, nanoparticles comprising the same, and use thereof for photodynamic therapy

Growing community of inventors

Castelnau le Lez, France

Magali Gary-Bobo