Hanmi Science Co., Ltd.

Hanmi Pharm. Co., Ltd.

Hanmi Holdings Co., Ltd.

Korea Institute of Science and Technology

Kolon Industries, Inc.

Catholic University Industry Academic Cooperation Foundation

Maeng Sup Kim

Young Gil Ahn

Mi Young Cha

Gwan Sun Lee

Bum Woo Park

Young Jin Ham

Young Hee Jung

Keuk Chan Bang

Mi Ra Kim

Jae Chul Lee

Kwee Hyun Suh

Tae Hee Ha

Seok Jong Kang

Seung Hyun Jung

Eun Joo Kwak

Ji Young Jeon

Kwang Ok Lee

Se Young Kim

Ju Yeon Lee

Myoung Gi Jo

Hwan Mook Kim

Jong Woo Kim

Hwan Geun Choi

Eun Young Kim

Ji Yeon Song

Tae Bo Sim

Jung Beom Son

Dong-wook Kim

Ji Eun Lee

Young Hoon Kim

Han Kyong Kim

Jong Won Choi

Yong Hoon An

Young-Gil Ahn

In Hwan Bae

Ji Young Song

Jeong Soo Kim

Jae Yul Choi

Jung Mi Hah

Young Kil Chang

Hwan Oh Kim

Mi Kyoung Lee

Ho Seok Kim

Seung Ah Jun

Eun Young Byun

Mi Young Ko

Jin Hee Kim

Tae Jin Choi

Tae Hun Song

Eun Jung Cho

Gha Seung Park

Dong-sik Park

Sun Young Jung

Jung Hee Han

Chang Gon Lee

Hae Kyoung Ju

Wha Ii Choi

Kyuhang Lee

Tae Gun Choi

Ki Sug Kim

Wha Il Choi

Mi Yon Shim

Sung Min Cho

Kyungik Lee

Sang Hoo Park

Eun Ju Jeon

Hyo Jeong Bang

In Soo Park

Myoung-Sil Ko

Kwang-Ok Lee

In Ho Yang

Keukchan Bang

Bo Im Choi

Myoung Sil Ko

Yun Jung Chae

Ji Hyeon Gong

Jae Heon Lee

Chang In Kim

Kyu Hang Lee

Dong-Wook Kim

Dong-Sik Park

Hwan Kim

The present invention relates to a novel bicyclic heteroaryl derivative, a pharmaceutically acceptable salt thereof, a hydrate thereof, and a solvate thereof having an improved inhibitory activity for protein kinases, and a pharmaceutical composition for preventing or treating an abnormal cell growth disorder comprising same as an active ingredient.

Bicyclic heteroaryl derivatives having inhibitory activity for protein kinase

The present invention relates to a novel fused pyrimidine derivative having an inhibitory activity for tyrosine kinases, and a pharmaceutical composition for preventing or treating cancers, tumors, inflammatory diseases, autoimmune diseases, or immunologically mediated diseases comprising same as an active ingredient.

Fused pyrimidine derivatives for inhibition of tyrosine kinase activity

The present invention relates to a thieno[3,2-d]pyrimidine derivative of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, which has an excellent inhibitory activity on protein kinases, and a pharmaceutical composition comprising the same is effective in preventing or treating abnormal cell growth diseases.

Thieno[3,2-d]pyrimidine derivatives having inhibitory activity on protein kinases

A method for preparing tetrazole methanesulfonic acid salts includes an acylation reaction using a novel 4-iodine-4H-chromene-2-carbothionic acid S-benzothiazole-2-yl ester. The method is advantageous that it can shorten a reaction time and improve safety as compared to conventional methods, and can prepare high-purity tetrazole methanesulfonic acid salts at a high yield rate without using a column chromatography method.

Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same

The present invention relates to a novel quinazoline derivative compound having the formula (1) as follows: with the constituents defined in claim, and a pharmaceutically acceptable salt thereof as a multiplex inhibitor, a method for the preparation thereof, and a pharmaceutical composition and a therapeutic composition comprising same as an active ingredient. The inventive quinazoline derivative as a multiplex inhibitor can selectively and effectively inhibit diseases caused by the overactivity of a tyrosine kinase.

Quinazoline derivatives as a multiplex inhibitor and method for the preparation thereof

Provided is a pharmaceutical composition comprising, as an active ingredient, a quinoline or quinazoline derivative of formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a solvate thereof, which is effective in the prevention and treatment of a cancer, inflammation, autoimmune diseases or neurodegenerative disorders which are induced by the overexpression of inhibitor of apoptosis proteins (IAPs).

Quinoline or quinazoline derivatives with apoptosis inducing activity on cells

According to the present invention, a method for preparing tetrazole methanesulfonic acid salts comprises an acylation reaction using a novel 4-iodine-4H-chromene-2-carbothionic acid S-benzothiazole-2-yl ester. The method of the present invention can shorten a reaction time and improve safety as compared to conventional methods, and can prepare high-purity tetrazole methanesulfonic acid salts at a high yield rate without using a column chromatography method.

Disclosed are a novel, high-yield method for preparing entecavir and intermediates used therein.

Method for preparing entecavir and intermediate used therein

The present invention provides a novel amide derivative of formula (I) and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising same as an active ingredient. 

Amide derivative for inhibiting the growth of cancer cells

The present invention relates to a novel quinazoline derivative and a pharmaceutically acceptable salt thereof for inhibiting the growth of cancer cells, a method for the preparation thereof and a pharmaceutical composition comprising same as an active ingredient.

Quinazoline derivatives for inhibiting cancer cell growth and method for the preparation thereof

The bioavailability of an anticancer agent is enhanced when the anticancer agent is administered together with a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.

P-glycoprotein inhibitor, method for preparing the same and pharmaceutical composition comprising the same

The present invention relates to a process for the production of benzene derivatives represented by formula (I), which are useful as intermediates for agricultural chemicals, fine chemical products or pharmaceuticals such as anti inflammatory analgesics. The process includes reacting a compound of chemical formula (II) with a hydroformylating agent and a halogenating agent. ##STR1##

Process for the production of benzene derivatives

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Seoul, South Korea

Maeng Sup Kim