Allergan, Inc.

Oculex Pharmaceuticals, Inc.

Vernon G. Wong

Mae W. L. Hu

Donald E., Jr. Berger

Mae W L Hu

Vernon G Wong

Donald E Berger, Jr

Jr Berger Donald E

Methods for treating inflammation-mediated conditions of the eye are described, comprising: implanting into the vitreous of the eye of an individual a bioerodible implant comprising a steroidal anti-inflammatory agent and a bioerodible polymer, wherein the implant delivers the agent to the vitreous in an amount sufficient to reach a concentration equivalent to at least about 0.05 &#x3bc;g/ml dexamethasone within about 48 hours and maintains a concentration equivalent to at least about 0.03 &#x3bc;g/ml dexamethasone for at least about three weeks.

Implants and methods for treating inflammation-mediated conditions of the eye

Methods for treating inflammation-mediated conditions of the eye are described, comprising: implanting into the vitreous of the eye of an individual a bioerodible implant comprising a steroidal anti-inflammatory agent and a bioerodible polymer, wherein the implant delivers the agent to the vitreous in an amount sufficient to reach a concentration equivalent to at least about 0.05 &mgr;g/ml dexamethasone within about 48 hours and maintains a concentration equivalent to at least about 0.03 &mgr;g/ml dexamethasone for at least about three weeks.

Methods for treating inflammation-mediated conditions of the eye

Controlled release devices are disclosed which are biocompatible and can be implanted into the eye. The devices have a core comprising a drug and a polymeric outer layer which is substantially impermeable to the entrance of an environmental fluid and substantially impermeable to the release of the drug during a delivery period, and drug release is effected through an orifice in the outer layer. These devices have an orifice area of less than 10% of the total surface area of the device and can be used to deliver a variety of drugs with varying degrees of solubility and or molecular weight. Methods are also provided for using these drug delivery devices.

Controlled-release biocompatible ocular drug delivery implant devices and methods

Growing community of inventors

Los Altos Hills, CA, United States of America

Mae W L Hu