Novo Nordisk A/s

Nokia Corporation

Mads Schenstroem Stefansen

Soeren Kjellerup Hansen

Bastian Gaardsvig Kjeldsen

Henrik Bengtsson

Klaus Bendix

Ilpo Kalevi Kauhaniemi

Matias Melander

Matti Kosonen

Esa-Sakari Maatta

Lars Eilertsen

Herman Scherling

Nikolaj Heiberg Bestle

Mikko Ukonaho

Thomas Bjarnsholt

Toke Folke Christensen

Henning Graaskov

Louise Wagner Noergaard

Claus Moser

The present invention relates to a pre-filled disposable injection device and a needle cannula in combination. The prefilled disposable injection device () is made from a housing () containing a non-exchangeable cartridge () for storing a liquid drug sufficient for a number of injections. The proximal end of the pre-filled injection device () carries the dose setting button () and the distal end carries the needle cannula () having a lumen () through which the settable dose is expelled. The distal end () of the needle cannula () is covered by a telescopic needle covering shield () which shield () can operate between a first position covering the tip () of the needle cannula () and a second retracted position allowing an injection to be performed. The shield () carries a cleaner () which cleans at least the tip () of the needle cannula () between successive injections such that the prefilled injection device can be used without changing the needle cannula () during its life cycle.

Pre-filled disposable injection device

A method of manufacturing one of a range of autoinjectors having cartridges (&#x2033;) with different preset fill volumes, the method comprising the steps of: a) providing a front body assembly (&#x2033;), b) providing a cartridge (&#x2033;) of given fill volume, c) providing a rear body assembly () comprising a spring-driven drive ram assembly () configured to drive the piston of a held cartridge (&#x2033;), d) providing a ram spacer member (&#x2033;), the ram spacer member defining a spacing geometry of length dimension (X', X&#x2033;, X&#x2032;&#x2033;, XS&#x2032;, XS&#x2033;, XS&#x2032;&#x2033;, XR&#x2032;, XR&#x2033;, XR&#x2032;&#x2033;) selected according to the fill volume of the cartridge (&#x2033;), and e) assembling a front body assembly (&#x2033;), the cartridge (&#x2033;), the ram spacer member (&#x2033;) and the rear body assembly () so that the ram spacer member (&#x2033;) is arranged axially between the drive ram assembly () of the rear body assembly () and the piston of a held cartridge (&#x2033;).

Method of manufacturing one of a range of autoinjectors

A system for optimizing a patient's basal insulin dosage regimen over time, adapted to determine from blood glucose values whether and by how much to vary a patient's present recommended amount of the insulin-containing drug in order to maintain the patient's future blood glucose level measurements within a predefined range, and wherein a given blood glucose value is disregarded if no patient-actuated operation being indicative of the administration of a dose of an insulin containing drug has been detected in a pre-defined amount of time prior to the determination of the given blood glucose value.

System for optimizing a drug dosage regimen over time

A needle unit () comprising: a needle hub () comprising a needle () and a needle shield (), wherein the needle hub () and the needle shield () are arranged to form a needle unit () where the needle hub is arranged displaceably inside the needle shield such that the needle hub is displaceable along an axis which is parallel with the longitudinal axis of the needle () between a shielded position and an exposed position. The needle hub () further comprises a first hub locking element () and a second hub locking element () and the needle shield () further comprises a first shield locking element () and a second shield locking element (), said first hub locking element () and said first shield locking element () engaging each other in the shielded position to establish a first releasable locking mechanism () between the needle hub () and the needle shield (), said second hub locking element () and said second shield locking element () engaging each other in the shielded position to establish a second locking mechanism () between the needle hub () and the needle shield (), both the first and second locking mechanisms () being arranged as shock proof locks, and where the first releasable lock mechanism () is arranged to engage with the lock release element () of the injection device () when the needle unit () is coupled to the injection device, said engagement allowing the first releasable lock mechanism () to be unlocked. The invention further provides an injection device comprising the needle unit and a method of assembling an injection device with the needle unit.

Needle unit with a lockable needle shield and an injection device comprising such a needle unit

An autoinjector () for expelling a single dose of drug from a drug cartridge () including a piston (), the autoinjector including: a base (), a needle () that is fixedly mounted relative to the base (), a plunger () adapted for cooperation with the piston (), an actuating spring () provided as a helical compression spring arranged to act on the plunger () by exerting an axial force on the plunger to drive the piston () distally, and a needle shield () axially movable relative to the base () between an extended position and a collapsed position. The autoinjector defines a lock () that is released when the needle shield () is moved from the extended position to the collapsed position. The lock () releases to enable relative rotation between plunger thread () and base thread () causing release of the plunger () from the initial axial position and expelling the dose of the drug.

Autoinjector having needle shield triggering

An injection device for expelling a dose of drug from a held cartridge () is described. A needle shield () is axially movable relative to a base () between a proximal collapsed position and a distal extended position. A needle shield lock comprises a deflectable lock element () operable to prevent the needle shield () from being moved towards the proximal collapsed position. A lock activator () associated with a plunger () exerts an activation force on the deflectable lock element when the plunger assumes a final position. A biasing means () is arranged to act between the lock activator () and the deflectable lock element (), the biasing means () being configured to resiliency transfer the activation force from the lock activator () to the deflectable lock element () to enable the needle shield () to become locked in the distal extended position but only when the plunger () assumes the final position.

Injection device having needle shield locking

A system comprising a state changing appliance and a drug delivery device, the state changing appliance comprising first interface means for rotationally locking to a first exterior portion of the drug delivery device, second interface means for rotationally locking to a second exterior portion of the drug delivery device, the first exterior portion and the second exterior portion being angularly displaceable relative to one another from a first relative position to a second relative position, which second relative position defines a set dose to be expelled by the drug delivery device, and limiter means for limiting a relative angular displacement between the first interface means and the second interface means.

State changing appliance for a drug delivery device

The invention relates to a mobile communications device comprising a housing, a transceiver in the housing, a keypad connected to the housing, and a display connected to the housing, wherein the housing comprises a first section movably connected to a second section of the housing by a multi-axis hinge, wherein a first axis of rotation of the hinge is provided at the first section of the housing and a second offset axis of rotation of the hinge is provided at the second section of the housing, and wherein the hinge comprises means for synchronizing rotation of the first and second sections relative to the hinge through a path of about 360 degrees. The invention further relates to a hinge for use therein.

Growing community of inventors

Copenhagen, Denmark

Mads Schenstroem Stefansen