University of California

Memorial Sloan Kettering Cancer Center

The United States Government as Represented by the Department of Veterans Affairs

Paganini Biopharma, Inc.

Madhuri Wadehra

Jonathan Braun

Anna M Wu

Lynn K Gordon

Kaori Shimazaki Dadgostar

Kathleen A Kelly

Kathy A Kelly

Robert Soslow

Kaori Shimazaki

Sathima Natarajan

Gary S Lazar

David G Telander

Shawn Morales

Provided herein are novel anti-EMP2 antibodies useful for the treatment and diagnosis of cancers that express or overexpress EMP2. In one aspect, provided herein is an isolated antibody that binds to Epithelial Membrane Protein 2 (EMP2), that includes heavy chain variable region and a light chain variable region. The heavy chain variable region includes three heavy chain complementary determining regions (HCDRs) and the light chain variable region includes three light chain variable regions (LCDRs). In some embodiments, the sequence of HCDR1 is SEQ ID NO: 11, the sequence of HCDR2 is SEQ ID NO: 12, the sequence of HCDR3 is SEQ ID NO: 13, the sequence of LCDR1 is SEQ ID NO:14, the sequence of LCDR2 is SEQ ID NO: 15, and the sequence of LCDR3 is SEQ ID NO: 16.

Antibodies for the treatment of cancers

The present invention provides methods and compositions useful in the treatment or prevention ofinfections and cancer. The methods and compositions inhibit the entry ofinto a host cell expressing EMP2 by interfering with the interaction between theand EMP2. The methods and compositions target cancers which express or overexpress EMP2 nucleic acids and polypeptides by targeting EMP2.

Antibodies which bind to epithelial membrane protein 2 (EMP2)

The present invention discloses methods of using epithelial membrane protein 2 (EMP2) as a biomarker for stratification of endometrial premalignancy, diagnosing, staging and imaging of endometrial neoplasia. Further, methods for identifying pharmaceutical/therapeutic modalities are described, including compositions which modulate glycolipid-enriched lipid raft microdomains (GEMs).

Methods for diagnosis and treatment of endometrial cancer

Methods of treating cancer by administering EMP2 antibodies

EMP2 antibodies and methods of use thereof for causing regression of a solid tumor or symptoms thereof

EMP2 antibodies and methods of use thereof causing regression of a solid tumor or symptoms thereof

Growing community of inventors

Manhattan Beach, CA, United States of America

Madhuri Wadehra