Hoffmann-la Roche Inc.

Madhukar Subraya Chodnekar

Milos Suchy

Albert Pfiffner

Ulrich Schwieter

Norbert Rigassi

Peter Loeliger

Rene Zurfluh

Ado Kaiser

Frank Kienzle

Rene Zurflun

Imidazoquinazolines of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are hydrogen, halogen, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy or C.sub.2-5 -alkoxyalkyl; or two of R.sup.1, R.sup.2 and R.sup.3 on adjacent carbon atoms taken together are methylenedioxy or ethylenedioxy; and R.sup.4 and R.sup.5 are hydrogen or C.sub.1-4 -alkyl, and their tautomers, as well as their physiologically compatible acid addition salts, are described. The compounds of formula I inhibit the aggregation of the blood platelets, as well as gastric acid secretion, and have activity on the circulatory system.

Imidazoquinazolines having pharmaceutical activity

Compounds of the formula ##STR1## wherein R.sup.1,R.sup.2,R.sup.3 and R.sup.4 are as hereinafter described, tautomers and salts thereof, are disclosed. The foregoing compounds inhibit the aggregation of blood platelets which renders them useful as therapeutic agents in the prophylaxis of thromboses. Furthermore, they are useful for the treatment and prophylaxis of cardiac insufficiency and cardiac failure, due to their inotropic activity without substantial tachycardia.

Imidazo[2,1-b]quinazolin-2(3H)-ones and pharmaceutical compositions for

Phenylcarbamates of the general formula: ##STR1## wherein R.sub.1 is lower alkyl, lower alkenyl, lower alkynyl, lower alkylcarbonyl, halogen-lower alkylcarbonyl or trichloromethylsulfenyl and R.sub.2 is hydrogen or lower alkyl, processes for their preparation; pesticidal compositions containing one or more of the phenylcarbamates as the active ingredient and methods for using the pesticide composition are disclosed.

Phenylcarbamates

Alkynyl, benzyl or phenyl, ethers and esters which are ring substituted with an oxy or a thio aliphatic chain. These ethers and esters are usful in killing and preventing the proliferation of insects by upsetting their hormonal balance.

Alkynyloxy-phenyl derivatives

Ethers, esters and amides of dodeca-2,4-dien 1-ols or 1-oic acids which have a methyl or ethyl side chain at the 11-position which are useful in killing and preventing proliferation of insects, by upsetting their hormone balance and a process for preparing these ethers, esters and amides including intermediates in this process.

Epoxy dodecadienamides

Alkynyl, benzyl or phenyl, ethers and esters which are ring substituted with an oxy or a thio aliphatic chain. These ethers and esters are useful in killing and preventing the proliferation of insects by upsetting their hormonal balance.

Compounds represented by the formula ##STR1## wherein R.sub.1 is hydrogen or lower alkyl containing 1-4 carbons and

Pesticides

The compound 2,3-(isopropylidenedioxy) phenyl-methyl [(trichloromethyl)-thio]-carbamate and its use as an insecticide and insecticidal compositions containing same compound.

Phenyl carbamate

Alkyl ethers of 2,3-dihydrobenzofuran where the alkyl chain may contain branched chains, unsaturated bonds, epoxy bridges, and may be substituted with halo, alkoxy, lower alkenyloxy, or lower alkynyloxy substituents useful in killing and preventing the proliferation of insects and other pests by upsetting their hormone balance.

Novel benzofuranyl pest retardants

Phenyloxy, phenylsulfinyl, phenylthio, phenylsulfonyl, benzyloxy, benzylthio, benzylsulfinyl, or benzylsulfonyl, alkyl or alkenyl derivatives wherein the alkyl or alkenyl group contains at least 7 carbon atoms which are useful in killing and preventing proliferation of insects by upsetting their hormone balance.

Phenyl derivatives

The present invention relates to polyene compounds, a process for their preparation, pesticidal compositions containing same, and a method of providing a locus free from pests using said pesticides, alone or in composition.

2,4-Dodecadienoic acid esters and use for insecticides

Polyene esters, ethers, carbamates, thioesters, amides, carbonyls and nitriles, containing at least one pair of conjugated double bonds, which are useful in killing pests, such as insects, and preventing the proliferation of such pests by upsetting their hormonal balance.

Propargyl esters of 7,11-substituted dodecadienoic acids

The present invention relates to phenyl derivatives, useful as insect hormones and with a method of providing a locus free of pests when using said phenyl derivatives or compositions containing same.

Propynyl benzyl ethers having juvenile hormone-like activity which are 4-halogen, lower alkyl, lower alkoxy or propynyloxy substituted or 3,4-lower alkylenedioxy substituted and which can also be 3,5- and/or .alpha.-substituted, and insecticide compositions that include at least one propynyl benzyl ether and that can also include a conventional insect-poison.

Growing community of inventors

Seltisberg, Switzerland

Madhukar Subraya Chodnekar