Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Idorsia Pharmaceuticals Ltd

Madhu Emmadi

Claney Lebev Pereira

Peter H Seeberger

Marilda Lisboa

Naeem Khan

Chakkumkal Anish

Sharavathi Guddehalli Parameswarappa

Bopanna Monnanda

Arne Von Bonin

Benjamin Schumann

Lennart Lykke

Christopher Martin

Adam Calow

Daniel Knopp

Fei-Fei Xu

Petra Menova

Paulina Kaplonek

The present invention relates to a synthetic saccharide of general formulate (I) that is related toPS-II cell-surface polysaccharide and conjugate thereof. Said synthetic saccharide, said conjugate and pharmaceutical composition containing said synthetic saccharide or said conjugate are useful for prevention and/or treatment of diseases associated with. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies againstbacteria.

Stable vaccine against

The present invention relates to immunogenic compositions comprising a conjugate of a saccharide fromserotype 8 and a carrier protein, and a mixture consisting of capsular polysaccharides fromserotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F individually conjugated to CRMcarrier protein, or a mixture consisting of capsular polysaccharides fromserotypes 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F and 23F individually conjugated to a carrier protein, wherein the capsular polysaccharides fromserotypes 1, 4, 5, 6B, 7F, 9V, 14, and 23F are individually conjugated to protein D, the capsular polysaccharide fromserotype 18C is conjugated to tetanus toxoid and the capsular polysaccharide fromserotype 19F is conjugated to diphtheria toxoid. Said compositions are useful for the prevention and/or treatment of diseases caused by

Pneumococcal polysaccharide-protein conjugate composition

The present invention relates to a synthetic saccharide of general formula (I) that is related toserotype 2 capsular polysaccharide, a conjugate thereof and the use of said saccharide and conjugate for raising a protective immune response in a human and/or animal host. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies againsttype 2 bacteria.

Synthetic vaccines againstserotype 2

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Berlin, Germany

Madhu Emmadi