Perspective Therapeutics, Inc.

Madeleine Eddy

Andrew W Knight

Daniel Mcalister

Edwin A Sagastume

A method for separating a lead radioisotope from a mixture comprising the lead radioisotope and a radioisotope of radium or thorium is provided, along with a system comprising a plurality of chromatographic columns. The system can include a first cartridge having a lead-complexing media that preferentially binds the lead radioisotope over radioisotopes of radium or thorium, and a second cartridge having a weak cationic exchange media, where a pH of a loading solution used to load the second cartridge is pH, and a pH of an eluent used to elute the lead radioisotope from the second cartridge is pH, and pHis greater than pH. The system can also comprise further third and fourth cartridges with chromatographic media to extract and purify the lead radioisotope, to provide a purified solution of lead radioisotope that can be used for medical and other purposes, such as in the labeling of radiopharmaceutical compounds.

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Lisle, IL, United States of America

Madeleine Eddy