University of Chicago

City of Hope

University of Alabama

Baylor College of Medicine

Maciej S Lesniak

Irina V Balyasnikova

David T Curiel

Karen S Aboody

Alexander J Annala

Stephen M G Gottschalk

Stephen MG Gottschalk

Provided are specific binding molecules, or fragments thereof, that bind to an epitope of IL13R&#x3b1;2, a receptor polypeptide preferentially found on the surface of cancer cells rather than healthy cells. Exemplary specific binding molecules are bispecific binding molecules that comprise a fragment of an IL13R&#x3b1;2 binding molecule and a peptide providing a second function providing a signaling function of the signaling domain of a T cell signaling protein, a peptide modulator of T cell activation, or an enzymatic component of a labeling system. Also provided are polynucleotides encoding such a specific binding molecule (e.g., bispecific binding molecule), vectors, host cells, pharmaceutical compositions and methods of preventing, treating or ameliorating a symptom associated with a cancer disease such as a solid tumor disease (e.g., glioblastoma multiforme).

IL13R&#x3b1;2 binding agents and use thereof

Car T-cells recognizing cancer-specific IL 13Ra2

Conjugates of IL13R&#x3b1;2 binding agents and use thereof in cancer treatment

In some embodiments, methods of killing tumor cells are provided. The methods may include contacting the tumor cell with a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective element and/or a capsid protein that binds a tumor-specific cell surface molecule. In another embodiment, methods of treating cancer are provided. The methods may include administering a therapeutically effective amount of a pharmaceutical composition to a subject, wherein the pharmaceutical composition includes a tropic cell that carries a modified oncolytic virus, wherein the virus comprises a tumor selective promoter element and/or a capsid protein that binds a tumor-specific cell surface molecule.

Tropic cell based virotherapy for the treatment of cancer

IL13R&#x3b1;2 binding agents and use thereof in cancer treatment

Growing community of inventors

Chicago, IL, United States of America

Maciej S Lesniak