Ablynx N.v.

Maarten Van Roy

Joost Alexander Kolkman

Els Anna Alice Beirnaert

Cedric Jozef Neotere Ververken

Catelijne Stortelers

Peter Vanlandschoot

Francis Descamps

Regorius Leurs

Maria Gonzalez Pajuelo

Philippe Van Rompaey

Pascal Gerard Merchiers

Martine Smit

David Andre Baptiste Maussang-Detaille

Johannes Joseph Wilhelmus De Haard

Michael John Scott Saunders

Christophe Blanchetot

Sven Jähnichen

Hendrik Adams

Els Beirnaert

Cedric Jozef Ververken

The present invention relates to amino acid sequences that are directed against/and or that can specifically bind Interleukin-6 Receptor (IL-6R) with improved affinity and/or avidity, and/or that have an improved efficacy and/or potency, and which are capable of (partially, or preferably totally) blocking the IL-6/IL-6R interaction and/or inhibit signalization through IL-6, IL-6R and/or the IL-6/IL-6R complex. The invention further relates to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides, to methods for preparing such amino acid sequences and polypeptides, to host cells expressing or capable of expressing such amino acid sequences or polypeptides, to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells, and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.

Methods for the preparation of compounds directed against interleukin-6 receptor (IL-6R)

The present invention relates to particular polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the present invention provides immunoglobulin single variable domains inhibiting CXCR7 mediated tumor growth.

Biological materials related to CXCR7

The present invention relates to amino acid sequences that are directed against G-protein coupled receptors (GPCRs), as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.

Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders

Methods of using IL-6R antibodies to block or reduce binding of IL-6 to IL-6R

Nucleic acids encoding IL-6R-binding polypeptides

Anti IL-6R polypeptides and compositions thereof

Anti-IL-6R polypeptides and pharmaceutical compositions thereof

Growing community of inventors

Zwijnaarde, Belgium

Maarten Van Roy