Koninklijke Philips Corporation N.V.

Maarten Van Herpen

Dirk Jan Broer

Derk Jan Wilfred Klunder

Emiel Peeters

Hendrik Roelof Stapert

Cristian Nicolae Presura

Derk J W Klunder

Marcello Balistreri

A pulsed radiation beam is directed toward a body structure having a configuration or physical characteristic that changes over time, the radiation being pulsed at a pulse modulation frequency. A detector detects acoustic oscillations set up in the body resultant from the incident pulsed radiation and produces an output signal representative of one or more parameters of the acoustic oscillations. A control system controls operation of the radiation delivery and a processor to process the detector output signal. The pulse modulation frequency of the pulsed radiation is changed over a predetermined range of modulation frequencies and the processor determines the structure resonant frequency from the detector output.

Investigation of body structures

A method and sensor for the detection of luminescence radiation generated by at least one luminophore is disclosed. In the context of the present invention the biosensor comprises a grid () defined as arrays of apertures with the apertures having a first dimension below and a second dimension above the diffraction limit of the excitation light () in a medium, a polarizer (), and luminophores () positioned in a volume selected from the group consisting of: the volume inside the apertures of the grid (), the volume in between the array of slits () and the polarizer () and a volume that extends into the polarizer (), wherein the grid () providing a transmission axis extending in a first direction and the polarizer () providing a transmission axis extending in a second direction, the first direction and the second direction being substantially perpendicular with respect to each other, wherein the excitation radiation () is polarized such that it is substantially suppressed by one of the at least one grid () and polarizer () and substantially not suppressed by the other of the at least one grid () and polarizer ().

Biosensor with one-dimensional sub-diffraction-limited apertures composed of a grid and a polarizer

The invention relates to an optical system that particularly allows an improved detection of signal light propagating from a light source () through a flat glass substrate (). SC-modes of this signal light that would normally be totally internally reflected at the backside () of the substrate () are coupled out by a first diffractive optical element DOE (). To map all signal light leaving the substrate () onto a single target location (), a focusing lens () and a second DOE () are disposed in the optical path behind the substrate (). The DOEs () may for example be a ID sinusoidal grating or a 2D blaze grating. The optical system may particularly be applied in an investigation apparatus for detecting multiple spots of a fluorescent sample material.

Optical system for mapping signal light onto a detector

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Heesch, Netherlands

Maarten Van Herpen