Technische Universiteit Eindhoven

Maarten Merkx

Menno Willem José Prins

Leonardus Josephus Van Ijzendoorn

Peter Zijlstra

Emilius Willem Adriaan Visser

Max Rose-Marie Wilhelmus Scheepers

Yan Ni

Leonardus Jospheus Ijzendoorn

Leonardus Josephus Ijzendoorn

Sambashiva Banala

Stijn Johannes Amanda Aper

Eva Anna Van Aalen

A method for sensing an analyte uses tethered particle motion. A functionalized particle has a first state in which the functionalized particle is bound to the surface and a second state in which the functionalized particle is not bound to the surface, where the functionalized particle switches between the first and second states depending on the presence and absence of the analyte, thereby changing motion characteristics of the functionalized particle depending on the presence of the analyte. A spatial coordinate parameter of the functionalized particle is measured by a detector, and a processor determines the presence/concentration of the analyte from changes in the measured spatial coordinate parameter.

Biosensor based on a tethered particle

A method for sensing an analyte uses tethered particle motion. A functionalized particle [] has a first state [] in which the functionalized particle is bound to the surface and a second state [] in which the functionalized particle is not bound to the surface, where the functionalized particle switches between the first and second states depending on the presence and absence of the analyte, thereby changing motion characteristics of the functionalized particle depending on the presence of the analyte. A spatial coordinate parameter of the functionalized particle is measured by a detector [], and a processor [] determines the presence/concentration of the analyte from changes in the measured spatial coordinate parameter.

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Best, Netherlands

Maarten Merkx