Abbott Laboratories Corporation

M Shawn Murphy

Mark A Hayden

Andrew G Fischer

Anthony Scott Muerhoff

Jeffrey B Huff

Thomas P Leary

Qiaoqiao Ruan

Sergey Y Tetin

Mark R Pope

Sophie Laurenson

Shelley R Holets-McCormack

Pathik H Soni

Lyle Yarnell

M Felicia Bogdan

Edna Prieto-Ballengee

Peter J Karabatsos

Lei Qiao

Dustin House

Richard Haack

Andrew S Schapals

Stefan Hershberger

Andrew T Fischer

Edna M Prieto-Ballengee

Felicia Bogdan

Thomas Leary

Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.

Devices and methods for sample analysis

Growing community of inventors

Allen, TX, United States of America

M Shawn Murphy