Leland Stanford Junior University

The United States Government As Represented by the Department of Veterans Affairs

M Peter Marinkovich

Alfred T Lane

Jayakumar Rajadas

Paul A Khavari

Jean Tang

Ngon T Nguyen

Zurab Siprashvili

Xiaoyu Xu

Jing Gao

Methods are provided for the cell-based delivery of collagen VII for the treatment of Epidermolysis Bullosa and corneal erosion. The disclosure also provides a composition and a pharmaceutical composition comprises, comprise, or alternatively consist essentially of, or yet further consist of a keratinocyte sheet or a corneal cell sheet.

Gene therapy for recessive dystrophic epidermolysis bullosa using genetically corrected autologous keratinocytes

Improved methods are provided for the recombinant synthesis of collagen, particularly collagen VII, in host cell, and for therapeutic delivery of the same. The recombinant collagen is produced in a host cell that has increased levels of prolyl-4-hydroxylase, relative to basal cell levels. The collagen produced by the methods of the invention has increased numbers of modified proline residues, relative to a recombinant collagen produced in a host cell having basal levels of prolyl-4-hydroxylase. The increased proline modification provides for a collagen having increased stability, including increased in vivo stability.

Production and delivery of a stable collagen

Disclosed are methods for the use of a truncated, recombinant laminin-511 for modifying hair growth as well as delivery devices, kits and methods for topically administering truncated, recombinant laminin-511. Furthermore disclosed are delivery devices, kits and methods using modulators of full-length laminin-511 expression or function to decrease hair growth in areas of unwanted hair growth.

Methods for modulating hair growth using truncated laminin-511

The present invention relates to compositions and methods for detecting and inhibiting squamous cell carcinoma using agents that target the laminin 5 alpha 3 G4-G5 domain.

Growing community of inventors

Redwood City, CA, United States of America

M Peter Marinkovich