Atherogenics, Inc.

Salutria Pharmaceuticals LLC

Ahterogenics, Inc.

M David Weingarten

James A Sikorski

Charles Q Meng

Liming Ni

Kimberly J Worsencroft

Raymond A Ng

Zhihong Ye

Wei Zhang

Christopher M Chappelow

Jacob E Simpson

Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of an inflammatory condition, in particular asthma. The compounds are of the general Formula I, or a pharmaceutically acceptable salt, ester, prodrug or derivative thereof: wherein:

Sulfonamide containing compounds for treatment of inflammatory disorders

Provided are methods for the separation of mono-substituted probucol derivatives from a mixture of both mono- and di-substituted probucol derivatives. In particular, methods are provided for the separation of mono-carboxy substituted probucol derivatives from a mixture of mono- and di-carboxy substituted probucol derivatives.

Process for the separation of probucol derivatives

A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different from that on the parent probucol molecule but which maintains the two free hydroxyl groups) with a Grignard reagent or a lithium reagent that produces a magnesium bromide or lithium salt of probucol or the probucol derivative. The probucol compound anion is then reacted with an ester or ether forming compound.

Process of preparing esters and ethers of probucol and derivatives thereof

Provided are methods for manufacturing compounds of Formula I wherein all substituents are described herein.

A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different from that on the parent probucol molecule but which maintains the two free hydroxyl groups) with a Grignard reagent or a lithium reagent that produces a magnesium bromide or lithium salt of probucol or the probucol derivative. The probucol compound anion anion is then reacted with an ester or ether forming compound.

The invention relates to compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds, wherein the compounds are of the following Formulas: or a pharmaceutically acceptable salt, ester or prodrug thereof, wherein the substituents are defined in the application. The invention further provides methods of treatment of inflammatory disorders by administering the compounds.

Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease

The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the application.

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Cumming, GA, United States of America

M David Weingarten