Millennium Pharmaceuticals Limited

M Alexandra Glucksmann

Rory A J Curtis

Keith Earl Robison

Andrew Dj Goodearl

The invention provides isolated nucleic acids molecules, designated NIP2b, NIP2cL, and NIP2cS nucleic acid molecules, which encode novel NIP2 family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing NIP2b, NIP2cL, and NIP2cS nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a NIP2b, NIP2cL, and NIP2cS gene has been introduced or disrupted. The invention still further provides isolated NIP2b, NIP2cL, and NIP2cS proteins, fusion proteins, antigenic peptides and anti-NIP2b, NIP2cL, and NIP2cS antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Isolated proteins and nucleic acid molecules having homology to the NIP2 protein and uses thereof

Method and compositions for treating type II diabetes; and type II diabetes diagnostics are disclosed

Therapeutic compositions and methods and diagnostic assays for type II

The invention provides methods for detecting the presence of a nucleic molecule encoding a muscarinic acetylcholine receptor 6 ('mACHR-6') family member.

Methods for detecting nucleic acid molecules encoding a member of the

The invention provides nucleic acids encoding a TRBP polypeptide, fragments thereof and homologs thereof The invention also provides TRBP polypeptides, fragments thereof and homologs thereof, and TRBP binding proteins. Methods for treating diseases or conditions characterized by an aberrant TRBP activity, e.g., by administering to the subject a TRBP therapeutic, are also disclosed. Diseases or conditions that can be treated according to the methods of the invention include thyroid-related disorders, metabolic disorders, and diabetes. Also disclosed are methods for predicting whether a subject is at risk of developing a disease associated with an aberrant TRBP activity, by determining, e.g., whether the subject has a genetic lesion in a TRBP gene and assays for identifying TRBP therapeutics.

Isolated TRBP polypeptides and uses therefor

Isolated nucleic acid encoding TRBP

The present invention provides isolated nucleic acid molecules encoding a G-protein coupled receptor that shows homology to the 5HT family of receptors. The present invention further provides vectors containing the nucleic acid molecules, hosts transformed or transfected with the nucleic acid molecules and methods of producing the G-protein coupled receptor.

Isolated nucleic acid molecules encoding a G-protein coupled receptor

Assays for determining whether a subject has or is at risk for developing type II diabetes, which are based on detecting the presence or absence of alterations in the hepatic nuclear factor 1 (HNF-1) gene or protein of the subject are disclosed.

Assays for diagnosing type II diabetes in a subject

Methods for identifying compounds, which modulate the bioactivity of human hepatic nuclear factor-1 (HNF-1), and which are therefore useful in treating type II diabetes are disclosed.

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Somerville, MA, United States of America

M Alexandra Glucksmann