Biolab Sanus Farmaceutica Ltda

Márcio Henrique Zaim

Sérgio Luiz Sacurai

Carlos Eduardo Da Costa Touzarim

Gilberto De Nucci

Artur Franz Keppler

A series of derivatives of 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,8-dione, mixtures thereof, their pharmaceutically acceptable salts, which are inhibitors of PDE-5, possessing vasodilatator properties and relaxing effects. In particular, compounds of formula (I), where R, R, R, and Rare defined herein, processes for the preparation of said compounds, pharmaceutical compositions containing them, as well as uses as inhibitors of the enzyme phosphodiesterase type 5 (PDE-5) in the treatment of the erectile dysfunction and PDE-5 inhibitor treatable disorders. 

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São Paulo, Brazil

Márcio Henrique Zaim