Cytrx Corporation

Richter Gedeon Nyrt.

N-gene Research Laboratories, Inc.

László Vígh

Gábor Balogh

Ibolya Horváth

Péter Literáti Nagy

Zsolt Török

László Ürögdi

Ede Márványos

Mária Kürthy

Attila Glatz

György Dormán

Andrea Jednákovits

Katalin Bíró

Beatrix Farkas

László Korányi

Sándor Bernáth

László Jaszlits

Mihály Barabás

Erzsébet Hegedüs

Éva Udvardy

Dénes Medzihradszky

Bea Mézes

Eszter Kovács

Balázs Sümegi

Ferenc Fülöp

Kálmán Tory

Botond Penke

Zoltán Szilvássy

József Mandl

Jenö Szilbereky

Ákos Hunya

Kálmán Takács

Jenó Szilbereky

Ernó Duda

Attila Kolonics

János Egri

Ernö Duda

The invention provides 1,4-dihydropyridine derivatives of formula (I) wherein Ris optionally substituted Caryl group or 5 to 6 membered heteroaryl group comprising 1 to 3 nitrogen atoms or other heteroatoms like oxygen and sulphur, and combinations thereof; Rand Rare independently hydrogen or Calkyl group; Rand Rare independently hydrogen, Calkyl group optionally substituted with amino, mono- or di(Calkyl)amino, or with 5 to 24 membered optionally fused heterocyclic ring attached by nitrogen and optionally comprising additional 1 to 3 N, O, S heteroatoms and optionally substituted with Calkyl group or Calkoxy group; Ris Calkyl, Ccycloalkyl, CcycloalkylCalkyl or arylCalkyl group; and stereoisomers including enantiomers, diastereomers, racemic mixtures, mixture of enantiomers and combination thereof, as well as polymorphs, pharmaceutically acceptable salts, solvates, esters and prodrugs thereof for use in the therapeutic or prophylactic treatment of a disorder mediated by heat shock proteins. 

1,4-dihydropyridine derivatives with HSP modulating activity

O-(3-piperidino-2-hydroxypropyl)-nicotinic amidoxime (BGP-15) or a pharmaceutically suitable acid addition salt thereof can be used for the prevention or reduction of weight gain or the reduction of the rate of body weight gain.

Prevention and treatment of obesity

A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

Method of enhancing cellular production of molecular chaperone, hydroxylamine derivatives useful for enhancing the chaperone production and the preparation thereof

Method of enhancing cellular production of molecular chaperon, hydroxylamine derivatives useful for enhancing the chaperon production and the preparation thereof

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Szeged, Hungary

László Vígh