Chinoin Pharmaceutical and Chemical Works Private Company Ltd.

Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Euroapi Hungary Limited Liability Company

Babolna Bio Ltd.

Bábolna Koörnyezetbioloögiai Központ Kft.

Babolna Kornyezetbiologiai Kozpont Kft.

László Takács

Zsuzsanna Kardos

Irén Hortobágyi

István Lászlófi

József Molnár

Gábor Havasi

Péter Buzder-Lantos

János Szilágyi

József Schmidt

Tamás Bán

Attila Halasi

Dániel Bajomi

János Daru

Vince Pozsár

József Tomcsik

Andrea Sántáné Csutor

Ervin Vajda

István Lászlofi

Róbertné Tormási

Ildikó Meleg

Kornélia Horváth

Judit Póti

Mariusz Kertész

Ibolya Fekete

Lajos Fekete

The present invention relates to a process for the preparation of a chiral prostaglandin enol intermediate of formula 1, comprising the steps of: separating a compound of formula 16-(R,S)-10 into its diastereomers by fractional crystallisation, reducing the 15-oxo group of the compound of formula 16-(R)-10, thereby obtaining a compound of formula 15-(R,S), 16-(R)-11, followed by removing the protecting group of the compound of formula 15-(R,S), 16-(R)-11, and isolating the compound of formula 1, and optionally, crystallizing the compound of formula 1. Optionally, the undesired isomer formed during fractional crystallization can be epimerized and further amount of the desired isomer can be recovered from the resulting mixture. The present invention also provides novel intermediates useful in the process. The invention further relates to a process for fractional crystallization of the compound of formula 16-(R,S)-10.

Process for the preparation of a chiral prostaglandin enol intermediate and intermediate compounds useful in the process

The invention provides a new enzimatic process for the preparation of chiral carboxylic acids, their salts and acid derivatives of the general formula (I) by enzymatic hydrolysis of racemic carboxylic acid ester of the general formula (II) and optionally subsequent esterification or acylation.

Process for the preparation of triple-bond-containing optically active carboxylic acids, carboxylate salts and carboxylic acid derivatives

The invention provides a stable epoprostenol sodium and a process for the preparation this pharmaceutically active ingredient.

Process for the preparation of epoprostenol sodium of enhanced stability

A process of preparing compounds of general formula I, by cuprate coupling of a vinyl cuprate of general formula II with a protected enone of general formula IV to produce a compound of general formula (V) removing the protecting groups of the compound of general formula (V) and purifying the compound of general formula (I) by chromatography; wherein the vinyl cuprate of formula (II) is prepared by reacting a vinyl stannane of formula III with copper halide CuX and alkyllithium R1Li and wherein an excess of the alkyllithium is decomposed before the said coupling reaction.

Process for the preparation and purification of misoprostol

The subject of the invention is a process for the preparation of high purity prostaglandin acid of the general formula II wherein the bonds marked with dotted lines represent single or double bonds wherein the double bonds may be cis- or trans oriented, Y represents O or CH, and Rstands for a phenyl group which is optionally substituted with CF, wherein the crude prostaglandin acid of the general formula II is purified by normal phase silicagel chromatography. 

Pocess for the preparation of high purity prostaglandins

The subject of the invention is a process for the preparation of Latanoprostene bunod of formula (I) with a purity higher than 95% where chromatography is used applying normal phase gravity silica gel column chromatography where the used silica gel is irregular silica gel or spherical silica gel an as eluent and eluent mixture consisting of an apolar and a polar solvent is used and if desired, contamination of the purified compound of formula I arising from the solvents are removed by silica gel filtration chromatography.

Preparation of latanoprostene bunod of desired, pre-defined quality by gravity chromatography

The invention provides a new process for the preparation of optically active Beraprost of formula (I) starting from racemic Beraprost alkyl ester through hydrolysis, enantiomer esterification, preparation of diacyl-Beraprost ester diastereomers and their separation and hydrolysis. 

Process for the preparation of optically active Beraprost

A consumable aqueous gel is provided for use in pest control. The gel sates the thirst of pests and increases the consumption of bait by pests. The gel is substantially free of biocides. The gel may be provided as a combination for use in a pest control device. The combination comprises an aqueous gel which is substantially free of biocides and a bait. A pest control device comprises a container having a first compartment containing an aqueous gel which is substantially free of biocides. A method of controlling pests comprises the step of deploying any of the aforementioned aqueous gel, combination according or pest control device. An aqueous gel which is substantially free of biocides may be used with or in a pest control device.

Consumable aqueous gel for use in pest control, a pest control device comprising an aqueous gel, and the use of an aqueous gel in a pest control device and in a method of controlling pests

The present invention relates to a device for controlling rodents. More specifically, the present invention relates to a device consisting of a combination of a solid and a pulpy bait (commonly known as 'fresh bait' or ' paste bait' in rodent control practice), wherein the solid part is a shaped paraffinized rodenticide bait with a rodenticide concentration which is lower than or equal to the rodenticide concentration of the combination and contains the pulpy rodenticide bait with a rodenticide concentration which is higher than or equal to the rodenticide concentration of the combination. The rodent control device according to the invention has an enhanced acceptance by the rodents and can preferably be fixed by a hole formed in the solid part preventing the rodents to take it away. Furthermore, the present invention relates to the preparation and use of such rodent control device.

Rodent control device

Growing community of inventors

Budapest, Hungary

László Takács