Egis Gyogyszergyar Rt.

Egis Gyogyszergyar Nyrt

László Gábor Hársing

Gyula Simig

József Barkóczy

György Lévay

István Gacsályi

Gábor Gigler

Tibor Mezei

Balázs Volk

Gábor Szénási

Katalin Pallagi

Krisztina Móricz

András Egyed

Csilla Leveleki

Rita Kapillerné Dezsöfi

Nóra Sziray

Zoltán Greff

Péter Kótay Nagy

Éva Schmidt

Miklós Végh

Bernadett Martonné Markó

István Ling

Endréné Flórian

Zoltán Rátkai

Géza Szabó

Gábor Szenasi

The present invention is concerned with new indol-2-one derivatives of Formula (I), which have favorable activity profile for the prophylaxis and treatment of disorders in the central nervous or in the cadiovascular system. 

Piperazine derivatives of alkyl oxindoles

The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein Rstands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; Rrepresents hydrogen or halogen; Rdenotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); Rstands for alkyl having 1-7 carbon atom(s); Rrepresents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R, Rand Reach stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or Rand Rtogether represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system. 

Piperazine derivatives of dialkyl oxindoles

The invention refers to novel 2,3-benzodiazepine derivatives of formula (I) and pharmaceutical compositions containing the same as the active ingredient. The novel compounds antipasmodic, muscle relaxant and neuroprotective activities. In formula I; X represents a hydrogen atom, a chloro atom or a methoxy group; Y stands for a hydrogen atom or a halo atom; Z means a methyl group or a chloro atom; R is a Calkyl group or a group of the formula &#x2014;NRR, wherein Rand Rrepresent, independently, a hydrogen atom, a Calkyl group, a Calkoxy group or a Ccycloalkyl group. 

2, 3-benzodiazepine derivatives and pharmaceutical compositions containing the same as the active ingredient

The invention relates to new piperidinyl-alkylamino-pyridazinone derivatives of the general Formula (I) (wherein R is hydrogen or C-alkyl; one of X and Y stands for hydrogen and the other represents a group of the general Formula (II) Hal stands for halogen; and n is 1 or 2) and pharmaceutically acceptable acid addition salts thereof a process for the preparation thereof and pharmaceutical compositions comprising said compounds. The compounds of the general Formula I exhibit anxiolytic effect and are useful in the treatment of anxiety 

Piperidinyl-alkylamino-pyridazinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing said compounds

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Budapest, Hungary

László Gábor Hársing