Richter Gedeon Nyrt.

László Borbély

József Dudás

Péter Jekkel

András Vass

Ferenc Haász

The invention relates to a process for the preparation of a phenolic hydroxy-substituted compound of the general formula (I) by desalkylation of an alkyl aryl ether of the general formula (II) by treatment with a thiourea/aluminum chloride reagent pair, in said general formulae Rstands for straight chain or branched Calkyl group; R, R, R, R, and Rhave the same or different meanings and stand for hydrogen or halogen atom, hydroxy, carboxy, nitro, oxo, Calkylcarbonyl, straight chain or branched alkyl or -alkoxy, or aryl group, or Rand Rtogether stand for a 5-7 membered ring or fused ring system; said 5-7 membered ring may be a partially saturated ring optionally substituted with an oxo group or can be an unsaturated ring; or said fused ring system may constitute with the first ring a steroid, preferably an estratriene derivative optionally substituted with an oxo or Calkylcarbonyloxy group in the 17 position. 

Growing community of inventors

Dorog, Hungary

László Borbély