Purdue Research Foundation

Virginia Tech Intellectual Properties, Inc.

Lynne S Taylor

Zoltan Kalman Nagy

Michael Harris

Gintaras V Reklaitis

Arun V Giridhar

Elcin Icten

Frederick Fiesser

Laura Hirshfield

Garth Jason Simpson

Kevin Edgar

Junyi Chen

Charles E Frazier

Brittany L B Nichols

Duangporn Wanapun

Laura I Mosquera-Giraldo

Umesh S Kestur

Ann Norris

Scott J Toth

Lisa J Mauer

Vivekanand Bhardwaj

A method for the synthesis of alkyl ω-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the ω-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid. Novel polysaccharides and hydrogels prepared according to these methods are also described.

Amphiphilic polysaccharides, polysaccharide-based hydrogels, and methods of manufacture

Systems and methods for delivering active ingredients, such as pharmaceutically active ingredients, to substrates are described herein. The active ingredients are delivered as fluids to a fluid-dispensing device for the creation of one or more drops for deposition onto substrates such as for the creation of microdoses. The invention further includes microdoses made by such processes.

Methods and systems for depositing active ingredients on substrates

The present disclosure relates to novel thiamine-organic acid salt, and the method of making the novel thiamine-organic acid salt.

Thiamine-organic acid salt

An apparatus and method for performing volume scanning of a sample comprised of chiral materials disposed in a matrix of non-chiral materials is disclosed. A laser is raster scanned in a plane of the volume such that the intensity of energy in the focal region is sufficient to generate second harmonic (SHG) energy. This energy is detected and may be processed into three dimensional images of the volume. The raster pattern is repeatedly stepped over an area of the sample so as to produce three dimensional images of time-dependent processes.

Imaging crystalline domains of small molecules

Growing community of inventors

West Lafayette, IN, United States of America

Lynne S Taylor