Wyeth

American Home Products Corporation

Lynne Padilla Greenblatt

Michael G Kelly

Ivo L Jirkovsky

Yvette L Palmer

Frances Christy Nelson

Richard Eric Mewshaw

Derek Cecil Cole

Gan Zhang

Reinhardt Bernhard Baudy

Steven Edward Lenicek

David Scott Nunn

The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a CNS disorder relating to or affected by the 5-HT6 receptor. 

Piperidinylchromen-6-ylsulfonamide compounds as 5-hydroxytryptamine-6 ligands

A compound having 5-HTreceptor activity, represented by the chemical formula wherein: The invention also includes compositions containing such a compound, as well as methods for using a compound of the invention.

Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents

The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a disorder relating to or affected by the 5-HT6 receptor.

Indolylalkylidenehydrazine-carboximidamide derivatives as 5-hydroxytryptamine-6 ligands

Piperazinyl-isatins

The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.

Chroman derivatives as 5-hydroxytryptamine-6 ligands

Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands

Trisubstituted-oxazole derivatives as serotonin ligands

This invention provides compounds of Formula 1 having the structure ##STR1## wherein: R.sub.1 is hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, benzyloxy, trifluoromethyl, chloro, bromo, or fluoro;

Oxazole derivatives as serotonin-1A receptor agonists

The compounds of the formula: ##STR1## in which Q is the quinoxaline nucleus; m is one of the integers 0, 1 or 2; n is one of the integers 1,2 or 3; or a pharmaceutically acceptable salt, alkyl ester or ##STR2## where R.sup.3 and R.sup.4 are, independently, hydrogen, nitro, halo or methoxy, are NMDA antagonists useful in the treatment and prevention of central nervous system related pathological conditions resulting from overstimulation by excitatory amino acids.

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Lambertville, NJ, United States of America

Lynne Padilla Greenblatt