Paratek Pharmaceuticals, Inc.

Lynne Garrity-Ryan

S Ken Tanaka

Evangelos L Tzanis

Amy L Manley

Paul McGovern

Judith N Steenbergen

Stephen Bai

The invention disclosed herein provides a method for treating Community-Acquired Bacterial Pneumonia (CABP) using 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, in either oral or IV doses or a combination of both.

9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (CABP)

The invention disclosed herein provides a method for treating urinary tract infection (UTI) using 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, in either oral or IV doses or a combination of both.

9-aminomethyl minocycline compounds and methods of use thereof in urinary tract infection (UTI) treatment

Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein the 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline is administered orally at a dose of about 450 mg per day for two consecutive days, then at a dose of about 300 mg per day for 5 or more days.

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Melrose, MA, United States of America

Lynne Garrity-Ryan