US Government As Represented by the Secretary of the Army

University of Massachusetts

Other

Lynne Ann Samuelson

Jayant Kumar

Ferdinando F Bruno

Ramaswamy Nagarajan

Virinder Singh Parmar

Susan Tripathy, Legal Representative

Ashok L Cholli

Sukant K Tripathy

Vijayendra Kumar

Michael S Sennett

Wei Liu

Kenneth A Marx

David L Kaplan

Rajesh Kumar

Arthur C Watterson

Bon-Cheol Ku

Heidi Schreuder-Gibson

K Shridhara Alva

Javant Kumar

Sucharita Roy

Soo-Hyoung Lee

Kris Senecal

Ashish Dhawan

Joseph A Akkara

Kethinni G Chittibabu

Lian Li

Christopher P Drew

Braja K Mandal

Ravi Mosurkal

Jin-An He

Susan J Braunhut

Mario J Cazeca

Donna McIntosh

Srinivasan Balasubramanian

Subhalakshmi Nagarajan

Sandip K Sengupta

Bonnie J Wiley

Klaudia Foley

Vincent B Tucci

A polymer is characterized by a repeat unit represented by Structural Formula (I): or a copolymer thereof. A crosslinked polymer characterized by a repeat unit represented by Structural Formula (II), (III), (IV) or (V): or a copolymer thereof, wherein at least one such repeat unit of a first polymer strand is crosslinked with at least one repeat unit of a second polymer strand by at least one bridging unit, the first and second polymer strands and the repeat unit being components of the crosslinked polymer.

Mixed organic and inorganic polymers

A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.

Synthesis of oligo/poly(catechins) and methods of use

Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein: The invention also includes methods of using and preparing these polymers.

Polymeric antioxidants

Nanometer scale structures, and methods of making the same are disclosed.

Nanometer scale structures

The following is an examiner's statement of reasons for allowance: an antioxidant polymer and method of preparing, the antioxidant comprising repeat units that include one or both of Structural Formulas (I) and (II) wherein R is &#x2014;H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group; Ring B is substituted with at least one &#x2014;H and at least one tert-butyl group or substituted or unsubstituted n-alkoxycarbonyl group is not taught nor fairly suggested by the prior art or any combination thereof.

A method of preparing a phenolic polymer comprising: a) protecting at least one hydroxyl group of a substituted or unsubstituted phenol represented by Structural Formula (XXIX), wherein: R, R, R, Rand Rare independently &#x2014;H, &#x2014;OH, &#x2014;NH, &#x2014;SH, a substituted or unsubstituted alkyl or aryl group, a substituted or unsubstituted alkoxycarbonyl or aryloxycarbonyl group, a substituted or unsubstituted alkoxy group or a saturated or unsaturated carboxylic acid group; or R, R, R, Ror R, in conjunction with an adjacent R, R, R, Ror R, forms a substituted or unsubstituted alkylene dioxy group; provided that at least one of R, R, R, Ror Ris a tert-butyl group-ethenyl--carboxylic acid or ester thereof, a substituted or unsubstituted alkylene dioxy group or a substituted or unsubstituted n-alkoxycarbonyl group, at least one of R, R, R, Ror Ris a hydroxyl group, and at least one of R, R, R, Rand Ris &#x2014;H; with a protecting group, wherein thereby obtaining one or more protected hydroxyl groups; and b) polymerizing the substituted or unsubstituted phenol, thereby obtaining the phenolic polymer.

An assembled hematin is formed by depositing hematin on an electrically charged substrate in one or more layers alternating with one or more layers of polyelectrolyte, preferably a cationic polymer. In a method for polymerizing an aromatic monomer, the assembled hematin is contacted with the monomer and a template, preferably an anionic polymer. In a method for polymerizing aniline, the aniline, sulfonated multi walled carbon nano tubes, PEG hematin and a reaction initiator are dispersed in water.

Assembled hematin, method for forming same and method for polymerizing aromatic monomers using same

Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein:

Hematin, a hydroxyferriprotoporphyrin, is derivatized with one or more non-proteinaceous amphipathic groups. The derivatized hematin can serve as a mimic of horseradish peroxidase in polymerizing aromatic monomers, such as aromatic compounds. These derivatized hematins can also be used as catalysts in polymerizing aromatic monomers, and can exhibit significantly greater catalytic activity than underivatized hematin in acidic solutions. In one embodiment, polymerization is in the presence of a template, along which aromatic monomers align. An assembled hematin includes alternating layers of hematin and a polyelectrolyte, which are deposited on an electrically charged substrate. Assembled hematin can also be used to polymerize aromatic monomers.

Polymerization of aromatic monomers using derivatives of hematin

The invention relates to a novel method for enzymatic polymerization which includes (1) obtaining a reaction mixture including a monomer, a template, and an enzyme; and (2) incubating the reaction mixture for a time and under conditions sufficient for the monomer to align along the template and polymerize to form a polymer-template complex. The template can be a micelle, a borate-containing electrolyte, or lignin sulfonate. Such a complex possesses exceptional electrical and optical stability, water solubility, and processibility, and can be used in applications such as light-weight energy storage devices (e.g., rechargeable batteries), electrolytic capacitors, anti-static and anti-corrosive coatings for smart windows, and biological sensors.

Enzymatic polymerization

A method of making a photovoltaic cell includes contacting a cross-linking agent with semiconductor particles, and incorporating the semiconductor particles into the photovoltaic cell.

Photovoltaic cell

Polymer-template complex produced by enzymatic polymerization

Growing community of inventors

Marlborough, MA, United States of America

Lynne Ann Samuelson