University of Florida Research Foundation Inc

Lynn S Peck

Eugene P Goldberg

James F Kirk

An improved method for preventing adhesions during surgery. Tissue surfaces and surgical articles involved in the surgery are coated with a solution of a hydrophilic, polymeric material prior to manipulation of the tissue during surgery. The polymeric material is (1) a substantially water-soluble polymer having at least one C.sub.n F.sub.2n+1 substituent wherein n.gtoreq.4, having a molecular weight of less than about 60,000; (2) a pharmaceutically acceptable salt or complex thereof; or (3) mixtures thereof. The concentration of the aqueous solution of the polymeric material is in the range of from about 0.1% to about 5.0% by weight, the molecular weight and concentration having values such that the aqueous solution is capable of providing wet coatings on the tissue.

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Gainesville, FL, United States of America

Lynn S Peck