Medtronic, Inc.

Honeywell International Inc.

Other

Lynn M Seifried

William D Wolf

Mary A Fraley

Joseph F Lessar

William John Taylor

Craig L Wiklund

Ronald F Hoch

Andrew J Ries

John E Kast

Robert T Sawchuk

James Strom

David L Thompson

David A Ruben

Ron Bardell

Douglas J Weiss

Patrick F Malone

Samuel F Haq

James E Volmering

Bill R Simmons

Tzu-Yu Wang

John E Nicholson

David B Engmark

Thomas M Nutzman

Lea A Nygren

Susan A Tettemer

Kevin K Tidemand

Pamela Wong

George C Johnstone

Jeffrey L Galvin

Dale W Schak

Lourdes O Kline

Jeff Galvin

A device includes a plasma separation membrane, a capillary channel positioned adjacent the plasma separation membrane to receive plasma from blood placed on the plasma separation membrane, at least one cuvette coupled to the capillary channel, a gas permeable membrane, and a distribution channel coupled to the capillary channel to provide plasma to the cuvette, wherein the cuvette is configured to hold an amount of plasma with reagent suitable for colorimetric assay by a tester to hold the device. Variations include the use of a quantitation channel to provide a selected amount of plasma and a mixing channel to mix plasma with a diluent.

Microfluidic separation of plasma for colormetric assay

A test cartridge includes an input channel to receive a liquid sample to be tested. A sample chamber is coupled to the input channel to receive the sample. An air permeable membrane is coupled between the sample chamber and ambient to prevent passage of the sample past the membrane and stop movement of the sample in the sample chamber.

Fluid stop for measured sample containment

A disposable blood analysis cartridge for analyzing a blood sample including an optical absorbance measurement channel is described. The optical absorbance measurement channel includes a plasma separation region and at least one sub channel including a cuvette that is in fluid communication with the plasma separation region and configured to receive a plasma portion of a blood sample that has been passed through the plasma separation region. A negative pressure may be applied to the cartridge to draw the sample through the plasma separation region and into the sub channel including the cuvette.

Disposable cartridge for fluid analysis

Methods and apparatuses are provided for an electrical device that employs a feedthrough including a hermetic seal that seals an interior region of the electrical device. The electrical device includes an electrical contact disposed within the interior region of the electrical device, and a wire terminal that includes an encircled portion that is encircled by the feedthrough, and a first end that electrically connects with said electrical contact. When the electrical device is constructed, the first end of the wire terminal is coated with a conductive metal that is more resistant to oxidation than the wire terminal. The first end of the wire terminal is secured to the electrical contact using a mechanical device such as a crimping connector or a spring connector.

Feedthrough apparatus with noble metal-coated leads

A feed-through assembly for an IMD and a method for fabricating the same are provided. The feed-through assembly has a ferrule having a first aperture disposed therethrough. An insulating member is disposed at least partially within the first aperture. The insulating member has a second aperture, an inside surface and an outside surface. A metallization region overlies at least a portion of the inside surface and at least a portion of the outside surface of the insulating member. The metallization region is formed of a first layer of titanium and a second layer of niobium. A portion of a terminal pin of platinum is disposed through the second aperture. A first brazing seal is disposed between the insulating member and the ferrule and a second brazing seal is disposed between the insulating member and the terminal pin. The first and second brazing seals are formed of gold.

Feed-through assemblies having terminal pins comprising platinum and methods for fabricating same

A capacitive filtered feedthrough assembly is formed in a solid state manner to employ highly miniaturized conductive paths each filtered by a discoid capacitive filter embedded in a capacitive filter array. A non-conductive, co-fired metal-ceramic substrate is formed from multiple layers that supports one or a plurality of substrate conductive paths and it is brazed to a conductive ferrule, adapted to be welded to a case, using a conductive, corrosion resistant braze material. The metal-ceramic substrate is attached to an internally disposed capacitive filter array that encloses one or a plurality of capacitive filter capacitor active electrodes each coupled to a filter array conductive path and at least one capacitor ground electrode. Each capacitive filter array conductive path is joined with a metal-ceramic conductive path to form a feedthrough conductive path. Bonding pads are attached to the internally disposed ends of each feedthrough conductive path, and corrosion resistant, conductive buttons are attached to and seal the externally disposed ends of each feedthrough conductive path. A plurality of conductive, substrate ground paths are formed extending through the co-fired metal-ceramic substrate between internally and externally facing layer surfaces thereof and electrically isolated from the substrate conductive paths. The capacitor ground electrodes are coupled electrically to the plurality of conductive, substrate ground paths and to the ferrule.

Capacitive filtered feedthrough array for an implantable medical device

Structures and methods relating to electrodes for incorporation into a feedthrough with a profile adapted for subcutaneous sensing of physiologic and cardiac signals. Electrode assemblies are adapted for integration with feedthrough to enable maximal electrode spacing, minimal myopotential electrical noise and provide reliable insulation from the IMD housing. Various structures and manufacturing processes are implemented to provide a large sensing surface with a low profile. The subcutaneous sensing electrode assembly provides a leadless sensing system and further enhances installation and follow-up procedures.

Subcutaneous sensing feedthrough/electrode assembly

A filtered feedthrough that does not block passage of gas in a helium leak test and enables testing of the hermeticity of the feedthrough while inhibiting high voltage arcing is disclosed in single filtered feedthrough and multiple filtered feedthrough array configurations. Each filtered feedthrough comprises a ferrule, an insulator, a feedthrough pin, a filter element, and a pre-formed insulative barrier or spacer located in an interior space between the feedthrough insulator and the filter element rather than a non-conductive adhesive filling the interior space. A gas flow path or pathway extends from the interior space to the exterior of the feedthrough bypassing each filter element. Any leak test gas applied in a hermeticity test and passing through defects in the feedthrough insulator or its attachment to the feedthrough pin or ferrule enters the interior space. The gas pathway extends from an interior space through one or more side wall hole of the ferrule and/or through one or more gap between the ferrule interior surface and the outer surface of the filter element.

Leak testable capacitive filtered feedthrough for an implantable medical device

A capacitive filter feedthrough assembly and method of making same are disclosed for shielding an implantable medical device such as pacemaker or defibrillator from electromagnetic interference or noise. A ferrule is adapted for mounting onto a conductive device housing by welding, soldering, brazing or gluing, and supports a terminal pin for feedthrough passage to a housing interior. A capacitive filter is mounted at the inboard side of a device housing, with capacitive filter electrode plate sets coupled respectively to the housing and the terminal pin by an electrically conductive combination of adhesive, brazing and soldering. In one embodiment of the invention, multiple capacitive filters are provided in an array within a common base structure, where each capacitive filter is associated with a respective terminal pin.

Adhesively- and solder-bonded capacitive filter feedthrough for

A capacitive filter feedthrough assembly and method of making the same are disclosed for shielding an implantable medical device such as pacemaker or defibrillator from electromagnetic interference or noise. A ferrule is adapted for mounting onto a conductive device housing by welding, soldering, brazing or gluing, and supports a terminal pin for feedthrough passage to a housing interior. A capacitive filter is mounted at the inboard side of a device housing, with capacitive filter electrode plate sets coupled respectively to the housing and the terminal pin by an electrically conductive combination of solder and brazing. In one embodiment of the invention, multiple capacitive filters are provided in an array within a common base structure, where each capacitive filter is associated with a respective terminal pin.

Capacitive filter feedthrough for implantable medical device

A capacitive filter feedthrough assembly and method of making the same are disclosed for shielding an implantable medical device such as pacemaker or defibrillator from electromagnetic interference or noise. A ferrule is adapted for mounting onto a conductive device housing by welding, soldering, brazing or gluing, and supports a terminal pin for feedthrough passage to a housing interior. A capacitive filter is mounted at the inboard side of a device housing, with capacitive filter electrode plate sets coupled respectively to the housing and the terminal pin by electrically conductive adhesive or brazing, or a combination of adhesive and brazing. In one embodiment of the invention, multiple capacitive filters are provided in an array within a common base structure, where each capacitive filter is associated with a respective terminal pin.

Adhesively-bonded capacitive filter feedthrough for implantable medical

A hermetically sealed implantable medical device is provided with a multi-pin arrangement including selected glass to metal or ceramic to metal seals for a feedthrough of the compression seal or matched seal type.

Growing community of inventors

Minneapolis, MN, United States of America

Lynn M Seifried